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Asialoglycoprotein receptor targeted micelles containing carborane clusters for effective boron neutron capture therapy of hepatocellular carcinoma

文献类型：期刊论文

作者Zhang, Taofeng1; Li, Guo2; Li, Sirui2; Wang, Zhen3; He, Dian3; Wang, Yu3; Zhang, Jinlong3; Li, Jili3; Bai, Zhongjie3; Zhang, Qiuping3
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
出版日期2019-10-01
卷号182页码:10
关键词Asialoglycoprotein Receptor Boron neutron capture therapy Hepatocellular carcinoma Micelles Liver Targetability
ISSN号0927-7765
DOI10.1016/j.colsurfb.2019.110397
通讯作者Liu, Bin(liubkg@lzu.edu.cn) ; Zhao, Quanyi(zhaoqy@lzu.edu.cn) ; Liu, Yang(liuy@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要The asialoglycoprotein receptor (ASGP-R) is viewed as an ideal target for hepatocyte-specific delivery. And the galactose residue is a promising ASGP-R ligand because of its high receptor affinity. Herein, a novel polymer based on PEGylated galactose was developed to achieve boron neutron capture therapy (BNCT) for active targeting hepatocellular carcinoma (HCC) by loading carborane clusters. Notably, the polymer could self-assemble into micelles with an average diameter of 135 nm under physiological conditions. The micelle had the high selectivity and low cytotoxicity to HepG2 cells (IC50 > 1000 mu M). Kinetically, the micelle had the higher uptake in HepG2 cells than the positive control group sodium borocaptate (BSH) in vitro. After the HepG2 cells were treated with the micelle, the cytoskeleton was changed and the migration ability was weakened during BNCT. Apoptosis was remarkably induced by breaking of DNA double strands of cancer cells. In addition, the concentration of B-10 in the tumor was 4.5 times higher than that of the BSH group at 4 h after the micelle administration in the tumor-bearing mice. The tumor/blood ratio of B-10 concentration reached over 25 at 24 h after micelle injection. In the normal mice, the micelles were mainly distributed among the liver and kidney tissues and could be effectively eliminated from the body within 24 h. No systemic toxicity was observed after administration. Thus, the carborane-containing PEGylated galactose micelles with ASGP-R targeting can be used as a promising therapeutic vector for effective boron neutron capture therapy of hepatocellular carcinoma.
WOS关键词SURFACE MODIFICATION ; POLYMERIC MICELLES ; NANOPARTICLES ; CANCER
资助项目National Natural Science Foundation of China[11575262] ; National Natural Science Foundation of China[21171079] ; Scientific Technology Research Projects of Gansu Province[18JR3RA377] ; Recruitment Program of Global Experts (1000 Talents Plan)
WOS研究方向Biophysics ; Chemistry ; Materials Science
语种英语
WOS记录号WOS:000489190200054
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; Scientific Technology Research Projects of Gansu Province ; Recruitment Program of Global Experts (1000 Talents Plan)
源URL[http://119.78.100.186/handle/113462/141752]  
专题中国科学院近代物理研究所
通讯作者Liu, Bin; Zhao, Quanyi; Liu, Yang; Zhang, Hong
作者单位1.Lanzhou Univ, Sch Nucl Sci & Technol, Inst Radiochem, Lanzhou, Gansu, Peoples R China
2.Lanzhou Univ, Sch Stomatol, Lanzhou, Gansu, Peoples R China
3.Lanzhou Univ, Sch Pharm, Lanzhou, Gansu, Peoples R China
4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Taofeng,Li, Guo,Li, Sirui,et al. Asialoglycoprotein receptor targeted micelles containing carborane clusters for effective boron neutron capture therapy of hepatocellular carcinoma[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,182:10.
APA Zhang, Taofeng.,Li, Guo.,Li, Sirui.,Wang, Zhen.,He, Dian.,...&Zhang, Hong.(2019).Asialoglycoprotein receptor targeted micelles containing carborane clusters for effective boron neutron capture therapy of hepatocellular carcinoma.COLLOIDS AND SURFACES B-BIOINTERFACES,182,10.
MLA Zhang, Taofeng,et al."Asialoglycoprotein receptor targeted micelles containing carborane clusters for effective boron neutron capture therapy of hepatocellular carcinoma".COLLOIDS AND SURFACES B-BIOINTERFACES 182(2019):10.

入库方式： OAI收割

来源：近代物理研究所

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