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Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis

文献类型：期刊论文

作者Su, Fengtao2; Smilenov, Lubomir B.1; Ludwig, Thomas3; Zhou, Libin2; Zhu, Jiayun2; Zhou, Guangming2; Hall, Eric J.1
刊名RADIATION ONCOLOGY
出版日期2010-02-22
卷号5期号:1页码:8
ISSN号1748-717X
DOI10.1186/1748-717X-5-15
英文摘要Background: In recent years data from both mouse models and human tumors suggest that loss of one allele of genes involved in DNA repair pathways may play a central role in genomic instability and carcinogenesis. Additionally several examples in mouse models confirmed that loss of one allele of two functionally related genes may have an additive effect on tumor development. To understand some of the mechanisms involved, we examined the role of monoallelic loss or Atm and Brca1 on cell transformation and apoptosis induced by radiation. Methods: Cell transformation and apoptosis were measured in mouse embryo fibroblasts (MEF) and thymocytes respectively. Combinations of wild type and hemizygous genotypes for ATM and BRCA1 were tested in various comparisons. Results: Haploinsufficiency of either ATM or BRCA1 resulted in an increase in the incidence of radiation-induced transformation of MEF and a corresponding decrease in the proportion of thymocytes dying an apoptotic death, compared with cells from wild-type animals. Combined haploinsufficiency for both genes resulted in an even larger effect on apoptosis. Conclusions: Under stress, the efficiency and capacity for DNA repair mediated by the ATM/BRCA1 cell signalling network depends on the expression levels of both proteins.
WOS关键词BREAST-CANCER SUSCEPTIBILITY ; TUMOR-SUPPRESSOR GENES ; DNA-DAMAGE ; ATAXIA-TELANGIECTASIA ; MUTATION CARRIERS ; HAPLOINSUFFICIENCY ; MICE ; REPAIR ; PREDISPOSITION ; HETEROZYGOTES
资助项目Office of Science (BER), US Department of Energy[DE-FG02-03ER63629] ; NASA[NAG 9-1519] ; Century Program of the Chinese Academy of Sciences[0760140BRO]
WOS研究方向Oncology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000275504600001
出版者BIOMED CENTRAL LTD
资助机构Office of Science (BER), US Department of Energy ; NASA ; Century Program of the Chinese Academy of Sciences
公开日期2011-04-20
源URL[http://ir.imp.cas.cn/handle/113462/7975]  
专题近代物理研究所_近代物理研究所知识存储（2010之前）
近代物理研究所_生物物理研究室
通讯作者Smilenov, Lubomir B.
作者单位1.Columbia Univ, Ctr Radiol Res, Med Ctr, New York, NY 10032 USA
2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
3.Columbia Univ, Inst Canc Genet, Med Ctr, New York, NY 10032 USA
推荐引用方式
GB/T 7714		 Su, Fengtao,Smilenov, Lubomir B.,Ludwig, Thomas,et al. Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis[J]. RADIATION ONCOLOGY,2010,5(1):8.
APA Su, Fengtao.,Smilenov, Lubomir B..,Ludwig, Thomas.,Zhou, Libin.,Zhu, Jiayun.,...&Hall, Eric J..(2010).Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis.RADIATION ONCOLOGY,5(1),8.
MLA Su, Fengtao,et al."Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis".RADIATION ONCOLOGY 5.1(2010):8.

入库方式： OAI收割

来源：近代物理研究所

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