Biodistribution of co-exposure to multi-walled carbon nanotubes and nanodiamonds in mice
文献类型：期刊论文
| 作者 | Qi Wei1; Li Zhan3 ; Bi Juanjuan1; Wang Jing1; Wang Jianjun1; Sun Taoli4; Guo Yi'an1; Wu Wangsuo1,2
|
| 刊名 | NANOSCALE RESEARCH LETTERS
 |
| 出版日期 | 2012-08-23 |
| 卷号 | 7期号:1页码:473-473 |
| 关键词 | Omwcnts Nds Biodistribution Excretion |
| ISSN号 | 1931-7573 |
| DOI | 10.1186/1556-276X-7-473 |
| 其他题名 | Biodistribution of co-exposure to multi-walled carbon nanotubes and nanodiamonds in mice |
| 文献子类 | Article |
| 英文摘要 | In this work, technetium-99 (Tc-99m) was used as the radiolabeling isotope to study the biodistribution of oxidized multi-walled carbon nanotubes (oMWCNTs) and/or nanodiamonds (NDs) in mice after intravenous administration. The histological impact of non-radiolabeled oMWCNTs or NDs was investigated in comparison to the co-exposure groups. Tc-99m-labeled nanomaterials had high stability in vivo and fast clearance from blood. After a single injection of oMWCNTs, the highest distribution was found in the lungs, with lower uptake in the liver/spleen. As for NDs injected alone, high distribution in the liver, spleen, and lungs was observed right after. However, uptake in the lungs was decreased obviously after 24 h, while high accumulation in the liver or spleen continued. After co-injection of oMWCNTs and NDs, oMWCNTs significantly affected the distribution pattern of NDs in vivo. Meanwhile, the increasing dose of oMWCNTs decreased the hepatic and splenic accumulation of NDs and gradually increased lung retention. On the contrary, the NDs had no significant effects on the distribution of oMWCNTs in mice. Histological photographs showed that oMWCNTs were mainly captured by lung macrophages, and NDs were located in the bronchi and alveoli after co-administration. oMWCNTs and NDs had different modes of micro-cells. In conclusion, the behavior and fate of NDs in mice depended strongly on oMWCNTs, but NDs had a small influence on the biodistribution and excretion pattern of oMWCNTs. |
| WOS关键词 | IN-VIVO ; TC-99M-C-60(OH)(X) ; RADIOTRACERS ; ACCUMULATION ; TOXICITY ; DELIVERY ; DAMAGE ; OXIDE ; FATE ; RATS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000310384400001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.186/handle/113462/47769]  |
| 专题 | 近代物理研究所_实验物理中心 |
| 通讯作者 | Wu Wangsuo |
| 作者单位 | 1.Lanzhou Univ, Radiochem Lab, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 4.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi Wei,Li Zhan,Bi Juanjuan,et al. Biodistribution of co-exposure to multi-walled carbon nanotubes and nanodiamonds in mice[J]. NANOSCALE RESEARCH LETTERS,2012,7(1):473-473. |
| APA | Qi Wei.,Li Zhan.,Bi Juanjuan.,Wang Jing.,Wang Jianjun.,...&Wu Wangsuo.(2012).Biodistribution of co-exposure to multi-walled carbon nanotubes and nanodiamonds in mice.NANOSCALE RESEARCH LETTERS,7(1),473-473. |
| MLA | Qi Wei,et al."Biodistribution of co-exposure to multi-walled carbon nanotubes and nanodiamonds in mice".NANOSCALE RESEARCH LETTERS 7.1(2012):473-473. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。