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Association between early-onset affective disorders and hypothyroidism in a larger number of psychiatric drug-free patients

文献类型：期刊论文

作者Zhao, Ying5,6,7; Wang, Na5,6; Chen, Jinni4; Guan, Qiongge3,5; Yuan, Xiang2; Shen, Yuan5,6; Zhang, Xiangyang1,7; Hao, Wei7; Zhang, Ruiling7; Zhai, Desheng4,7
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2022-02-15
卷号299页码:31-36
ISSN号0165-0327
关键词Early onset Affective disorder Drug-free Hypothyroidism
DOI10.1016/j.jad.2021.11.061
通讯作者Zhang, Ruiling(zhangruilingxx@163.com) ; Zhai, Desheng(zds@xxmu.edu.cn)
英文摘要Aims: We aimed to assess the association between early onset of affective disorders and hypothyroidism in a larger number of psychiatric drug-free patients with bipolar disorder (BD) or major depressive disorder (MDD). Methods: Early onset of affective disorders was defined as BD and MDD developed before the age of 22 years. The hypothyroidism hierarchy were diagnosed biochemically and included subclinical and overt hypothyroidism in this study. Demographic and clinical data including diagnosis, illness duration and thyroid function parameters (TSH, T4, FT4, T3 and FT3) at admission were collected from patients' records. Adjusted odds ratio (OR) and 95% confidence interval (CI), which were estimated by logistic regression model, were used to assess the association between early-onset affective disorder and hypothyroidism. Results: The prevalence of hypothyroidism in early-onset affective disorders was higher than that in late-onset patients (in BD, 9.4% vs. 6.2%, chi 2 = 6.020, P = 0.014; and in MDD 12.7% vs. 6.6%, chi 2 = 13.295, P < 0.001). Early-onset affective disorders were 2.097 times (95% CI: 1.409-3.123) more likely to have hypothyroidism compared with late-onset patients, after adjustment for age, gender, duration of illness and mood episode (adjusted OR: 1.965, 95% CI: 1.198-3.221 in BD, and adjusted OR: 2.831, 95% CI: 1.378-5.817 in MDD, respectively). Limitation: Because of the cross-sectional design of this study, we were unable to sort out causality between earlyonset affective disorders and hypothyroidism. Conclusion: Early-onset affective disorder may be associated with higher prevalence of hypothyroidism.
收录类别SCI
WOS关键词BIPOLAR DISORDER ; SUBCLINICAL HYPOTHYROIDISM ; PHYSICAL ILLNESS ; FOLLOW-UP ; DEPRESSION ; POPULATION ; LITHIUM ; RISK ; GENETICS ; SYSTEM
资助项目Henan Key Science and Technologies development program[202102310084] ; Henan Key Science and Technologies development program[12,102,310,102] ; Support project of scientific and technological innovation team in Universities of Henan Province[20IRTSTHN027] ; Henan Key Medical Science and Technologies development program[SBGJ2018058]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000737054400005
资助机构Henan Key Science and Technologies development program ; Support project of scientific and technological innovation team in Universities of Henan Province ; Henan Key Medical Science and Technologies development program
源URL[http://ir.psych.ac.cn/handle/311026/41753]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Ruiling; Zhai, Desheng
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Henan Univ Sci & Technol, Affiliated Hosp 1, Coll Clin Med, Med Coll, Luoyang 471003, Peoples R China
3.Xinxiang Med Univ, Sch Life Sci & Technol, Xinxiang 453003, Henan, Peoples R China
4.Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan, Peoples R China
5.Xinxiang Key Lab Clin Psychopharmacol, Xinxiang 453003, Henan, Peoples R China
6.Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China
7.Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Ying,Wang, Na,Chen, Jinni,et al. Association between early-onset affective disorders and hypothyroidism in a larger number of psychiatric drug-free patients[J]. JOURNAL OF AFFECTIVE DISORDERS,2022,299:31-36.
APA Zhao, Ying.,Wang, Na.,Chen, Jinni.,Guan, Qiongge.,Yuan, Xiang.,...&Zhai, Desheng.(2022).Association between early-onset affective disorders and hypothyroidism in a larger number of psychiatric drug-free patients.JOURNAL OF AFFECTIVE DISORDERS,299,31-36.
MLA Zhao, Ying,et al."Association between early-onset affective disorders and hypothyroidism in a larger number of psychiatric drug-free patients".JOURNAL OF AFFECTIVE DISORDERS 299(2022):31-36.

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来源：心理研究所

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