Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder
文献类型：期刊论文
| 作者 | Mu, Li5,6; Yu, Feng4; Xia, Jiejing4; Lang, XiaoE3; Haque, Anam2; Wu, Hanjing Emily2; Zhang, Xiang Yang1
|
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2021-12-01 |
| 卷号 | 295页码:284-290 |
| 关键词 | Bipolar disorder Body mass index Homocysteine Depressive episodes |
| ISSN号 | 0165-0327 |
| DOI | 10.1016/j.jad.2021.08.032 |
| 通讯作者 | Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background: Bipolar disorder (BD) has been associated with an increased prevalence of weight gain and abnormally elevated plasma homocysteine (Hcy) levels. However, the relationship between BMI and Hcy in BD patients has not been investigated. This study aimed to explore this relationship in Chinese patients with BD. Methods: Plasma Hcy levels, socio-demographic parameters, clinical and anthropometric data were collected from 195 BD inpatients and 84 healthy controls. The level of plasma Hcy was determined by high-performance liquid chromatography. Body mass index (BMI) was calculated by body weight divided by the square of the height. The participants were divided into a high BMI group and a low BMI group using 24 kg/m(2) as a threshold. Results: The prevalence of high BMI was slightly elevated in BD patients in comparison to healthy controls. Patients with elevated BMI had significantly higher Hcy levels than patients with low BMI. Hcy level was an independent contributor of the occurrence of high BMI in BD patients. The level of Hcy was positively correlated with BMI in BD patients. In addition, depressive episodes of BD were positively correlated with the prevalence of high BMI and married BD patients were more likely to have high BMI levels. Conclusions: There is a close relationship between BMI and plasma Hcy levels in patients with BD, suggesting that Hcy may be an important indicator for BD-induced weight gain. This finding provides a new avenue for weight management of BD patients and to help avoid the potential risk of cardiovascular diseases. |
| 收录类别 | SCI |
| WOS关键词 | BODY-MASS INDEX ; MAJOR DEPRESSIVE DISORDER ; METABOLIC SYNDROME ; PHYSICAL-EXERCISE ; OBESITY ; RISK ; PREVALENCE ; OVERWEIGHT ; SCHIZOPHRENIA ; ADOLESCENTS |
| 资助项目 | CAS Pioneer Hundred Talents Program |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000741334700037 |
| 出版者 | ELSEVIER |
| 资助机构 | CAS Pioneer Hundred Talents Program |
| 源URL | [http://ir.psych.ac.cn/handle/311026/41807]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China 4.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 5.Key Lab Brain & Cognit Neurosci, Dalian, Liaoning, Peoples R China 6.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mu, Li,Yu, Feng,Xia, Jiejing,et al. Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,295:284-290. |
| APA | Mu, Li.,Yu, Feng.,Xia, Jiejing.,Lang, XiaoE.,Haque, Anam.,...&Zhang, Xiang Yang.(2021).Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder.JOURNAL OF AFFECTIVE DISORDERS,295,284-290. |
| MLA | Mu, Li,et al."Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder".JOURNAL OF AFFECTIVE DISORDERS 295(2021):284-290. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。