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Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder

文献类型：期刊论文

作者Li, Xiao-Yan8; Tabarak, Serik5,6,7; Su, Xiu-Ru8; Qin, Zengchang3; Chai, Yuan3; Zhang, Shunyu3; Wang, Ke-Qiang8; Guan, Heng-Yong8; Lu, Shu-Lan8; Chen, Ying-Nan8
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2021-12-01
卷号295页码:264-270
关键词Major depressive disorder Suicide attempt Risk factor Machine learning XG-boost
ISSN号0165-0327
DOI10.1016/j.jad.2021.08.028
通讯作者Li, Su-Xia(li313@bjmu.edu.cn) ; Zhang, Xiang-Yang(zhangxy@psych.ac.cn)
英文摘要Background: Major depressive disorder (MDD) is the most common mental disorder associated with suicide attempts. When a patient first visits the clinic, clinicians are often expected to make concrete diagnose about acute suicidal risk. However, the timeliness of suicide attempts correlates with patients with MDD has not been tested. Methods: We divided 1718 first-episode and untreated MDD outpatients into those who did not have suicide attempts (non-attempts), recent suicide attempters (<= 14 days before assessment) and long - dated suicide attempters (> 30 days before assessment). Positive Symptom Scale of Positive and Negative Syndrome Scale (PANSS), the 17-item Hamilton Depression Scale, 14 - item Hamilton Anxiety Scale, and clinical global impression of severity scale (CGI-S) was assessed. Body mass index, some glycolipid metabolism and thyroid hormone parameters were measured. A gradient-boosted decision trees statistical model was used to generate equally weighted classification for distinguishing recent and long - dated suicide attempters from non-attempts. Results: The classifier identified higher excitement, hostility, anxiety, depression symptoms and higher free thyroxine (FT4) as risk factors for recent suicide attempters with an estimated accuracy of 87% (sensitivity, 59.1%; specificity, 61.2 %). For long - dated suicide attempters' risk factors, single status, higher anxiety and hostility symptoms, higher LDLC and lower BMI, the estimated accuracy was 88% (sensitivity, 52.8%; specificity, 49.6%). Conclusions: Risk factors for suicide attempt among patients with MDD can be identified by integrating demographic, clinical, and biological variables as early as possible during the first time see a doctor.
收录类别SCI
WOS关键词TOWER-OF-BABEL ; 1ST-EPISODE PSYCHOSIS ; MENTAL-DISORDERS ; FOLLOW-UP ; BEHAVIOR ; NOMENCLATURE ; PREDICTORS ; MODEL ; OPUS
资助项目Natural Science Foundation of China[81871071] ; Natural Science Foundation of China[81171251] ; Natural Science Foundation of Beijing[7162101]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:000741334700035
出版者ELSEVIER
资助机构Natural Science Foundation of China ; Natural Science Foundation of Beijing
源URL[http://ir.psych.ac.cn/handle/311026/41813]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Su-Xia; Zhang, Xiang-Yang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Beihang Univ, Sch Automat Sci & Elect Engn, Intelligent Comp & Machine Learning Lab, Beijing 100191, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Beijing, Peoples R China
5.Peking Univ, Natl Inst Drug Dependence, Beijing Key Lab Drug Dependence, Beijing, Peoples R China
6.Peking Univ, McGovern Inst Brain Res, PKU IDG, Beijing, Peoples R China
7.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
8.Rong Jun Hosp, Baoding 071000, Hebei, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xiao-Yan,Tabarak, Serik,Su, Xiu-Ru,et al. Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,295:264-270.
APA Li, Xiao-Yan.,Tabarak, Serik.,Su, Xiu-Ru.,Qin, Zengchang.,Chai, Yuan.,...&Zhang, Xiang-Yang.(2021).Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,295,264-270.
MLA Li, Xiao-Yan,et al."Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 295(2021):264-270.

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来源：心理研究所

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