Stereo-selective synthesis of non-canonical gamma-hydroxy-alpha-amino acids by enzymatic carbon-carbon bond formation
文献类型：期刊论文
| 作者 | Zhang, Rui1; Tan, Jiamu1,2; Luo, Zhenzhen3; Dong, Haihong1; Ma, Ningshan1; Liao, Cangsong1,2,3 |
| 刊名 | CATALYSIS SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2021-10-04 |
| 页码 | 6 |
| ISSN号 | 2044-4753 |
| DOI | 10.1039/d1cy00955a |
| 通讯作者 | Liao, Cangsong(csliao@simm.ac.cn) |
| 英文摘要 | Carbon-carbon (C-C) bond formation is the fundamental reaction type in organic synthesis. Biocatalytic methods for C-C bond formation have been limited to a few types of enzymes. In this report, we demonstrated the capability of a PLP-dependent enzyme ApUstD performing both C-C bond activation and asymmetric C-C bond formation, which resulted in non-canonical gamma-hydroxy-alpha-amino acids. The reaction showed high efficiency (conversion up to 98%), stereo-selectivity (ratio up to >97 : 3), a broad substrate scope (25 isolated examples) and significant simplicity. Our results have extended the biocatalytic function of PLP-dependent enzymes for asymmetric C-C formation. |
| WOS关键词 | THREONINE ALDOLASE ; BIOCATALYSTS |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China (NSFC)[22071259] ; Science and Technology Commission of Shanghai Municipality[20ZR1468000] ; Shanghai Pujiang Program[20PJ1415700] ; Shanghai Super Postdoctoral Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000709503500001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298344]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liao, Cangsong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Chem Biol Res Ctr, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rui,Tan, Jiamu,Luo, Zhenzhen,et al. Stereo-selective synthesis of non-canonical gamma-hydroxy-alpha-amino acids by enzymatic carbon-carbon bond formation[J]. CATALYSIS SCIENCE & TECHNOLOGY,2021:6. |
| APA | Zhang, Rui,Tan, Jiamu,Luo, Zhenzhen,Dong, Haihong,Ma, Ningshan,&Liao, Cangsong.(2021).Stereo-selective synthesis of non-canonical gamma-hydroxy-alpha-amino acids by enzymatic carbon-carbon bond formation.CATALYSIS SCIENCE & TECHNOLOGY,6. |
| MLA | Zhang, Rui,et al."Stereo-selective synthesis of non-canonical gamma-hydroxy-alpha-amino acids by enzymatic carbon-carbon bond formation".CATALYSIS SCIENCE & TECHNOLOGY (2021):6. |
入库方式： OAI收割
来源：上海药物研究所
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