中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages

文献类型：期刊论文

作者Wang, Qiaoqiao1,2,3,4; Zhang, Tian5; Ke, Chang-Qiang1,2; Tang, Chunping1,2; Yao, Sheng1,2; Lin, Ligen5; Ye, Yang1,2,3,4
刊名PHYTOCHEMISTRY
出版日期2021-12-01
卷号192页码:10
关键词Artemisia codonocephala Asteraceae Guaianolides Anti-inflammation IL-1 beta NLRP3
ISSN号0031-9422
DOI10.1016/j.phytochem.2021.112955
通讯作者Ye, Yang(yye@simm.ac.cn)
英文摘要Sesquiterpene lactones supply a variety of scaffolds for the development of anti-inflammatory drugs. In this study, eight undescribed guaianolides, i.e., lavandolides A-H, were isolated from the whole plants of Artemisia codonocephala, together with five known analogues. Their planar structures and relative configurations were elucidated by spectroscopic measurements, and their absolute configurations were determined by electronic circulardichroism spectra and single crystal X-ray diffraction experiments. The nitric oxide inhibitory effect of all the isolates was assessed on lipopolysaccharide stimulated THP-1 macrophages. Lavandolide D showed a potent inhibitory effect on NO production, with IC50 values of 3.31 +/- 0.74 mu M. Furthermore, lavandolide D inhibited NOD-, LRR-and pyrin domain-containing protein 3 inflammasome-mediated interleukin-1 beta production through activating autophagy.
WOS关键词SESQUITERPENE LACTONES ; GENUS
资助项目Science and Technology Commission of Shanghai Municipality[20430780300] ; Science and Technology Commission of Shanghai Municipality[19431908100] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002] ; University of Macau[MYRG2018-00037-ICMS]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000704441000016
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/298424]  
专题新药研究国家重点实验室
通讯作者Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Qiaoqiao,Zhang, Tian,Ke, Chang-Qiang,et al. Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages[J]. PHYTOCHEMISTRY,2021,192:10.
APA Wang, Qiaoqiao.,Zhang, Tian.,Ke, Chang-Qiang.,Tang, Chunping.,Yao, Sheng.,...&Ye, Yang.(2021).Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages.PHYTOCHEMISTRY,192,10.
MLA Wang, Qiaoqiao,et al."Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages".PHYTOCHEMISTRY 192(2021):10.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。