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Progression and Regression of Abdominal Aortic Aneurysms in Mice

文献类型：期刊论文

作者Ding, Yu-chao1,2; Zhang, Xian-jing1; Zhang, Ji-xiu1; Zhai, Zi-yi1,2; Zhang, Mei-xia2; Jiang, Bao-hong1
刊名CURRENT MEDICAL SCIENCE
出版日期2021-10-13
页码8
关键词abdominal aortic aneurysm disease progression disease regression elastogenesis lysyl oxidase
ISSN号2096-5230
DOI10.1007/s11596-021-2425-z
通讯作者Zhang, Mei-xia(mxzhang@cmu.edu.cn) ; Jiang, Bao-hong(jiangbh@simm.ac.cn)
英文摘要Objective Abdominal aortic aneurysm (AAA) is a significant medical problem with a high mortality rate. Nevertheless, the underlying mechanism for the progression and regression of AAA is unknown. Methods Experimental model of AAA was first created by porcine pancreatic elastase incubation around the infrarenal aorta of C57BL/6 mice. Then, AAA progression and regression were evaluated based on the diameter and volume of AAA. The aortas were harvested for hematoxylin-eosin staining (HE), orcein staining, sirius red staining, immunofluorescence analysis and perls' prussian blue staining at the indicated time point. Finally, beta-aminopropionitrile monofumarate (BAPN) was used to explore the underlying mechanism of the regression of AAA. Results When we extended the observation period to 100 days, we not only observed an increase in the AAA diameter and volume in the early stage, but also a decrease in the late stage. Consistent with AAA diameter and volume, the aortic thickness showed the same tendency based on HE staining. The elastin and collagen content first degraded and then regenerated, which corresponds to the early deterioration and late regression of AAA. Then, endogenous up-regulation of lysyl oxidase (LOX) was detected, accompanying the regression of AAA, as detected by an immunofluorescent assay. BAPN and LOX inhibitor considerably inhibited the regression of AAA, paralleling the degradation of elastin lamella and collagen. Conclusion Taken together, we tentatively conclude that endogenous re-generation of LOX played an influential role in the regression of AAA. Therefore, regulatory factors on the generation of LOX exhibit promising therapeutic potential against AAA.
WOS关键词LYSYL OXIDASE ; MATRIX ; MODEL ; INHIBITION ; CELLS
资助项目National Natural Science Foundation of China[81770478] ; National Natural Science Foundation of China[81970395] ; Shanghai Science and Technology Development Foundation[21S21901900] ; Inter-governmental Science and Technology Innovation Cooperation Program, Ministry of Science and Technology of China[2021YFE0111300] ; Biological Resources Programme, Chinese Academy of Sciences[KFJ-BRP-008]
WOS研究方向Research & Experimental Medicine
语种英语
WOS记录号WOS:000706939900001
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/298427]  
专题中国科学院上海药物研究所
通讯作者Zhang, Mei-xia; Jiang, Bao-hong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.China Med Univ, Coll Basic Med Sci, Shenyang 110122, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Yu-chao,Zhang, Xian-jing,Zhang, Ji-xiu,et al. Progression and Regression of Abdominal Aortic Aneurysms in Mice[J]. CURRENT MEDICAL SCIENCE,2021:8.
APA Ding, Yu-chao,Zhang, Xian-jing,Zhang, Ji-xiu,Zhai, Zi-yi,Zhang, Mei-xia,&Jiang, Bao-hong.(2021).Progression and Regression of Abdominal Aortic Aneurysms in Mice.CURRENT MEDICAL SCIENCE,8.
MLA Ding, Yu-chao,et al."Progression and Regression of Abdominal Aortic Aneurysms in Mice".CURRENT MEDICAL SCIENCE (2021):8.

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来源：上海药物研究所

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