Picomolar antimalarial agent from a Chinese medicinal plant
文献类型：期刊论文
| 作者 | Zhou, Bin1; Zimbres, Flavia M.2; Butler, Joshua H.2; Xu, Cheng-Hui1; Haney, Reagan S.2; Wu, Yan1; Cassera, Maria B.2; Yue, Jian-Min1
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| 刊名 | SCIENCE CHINA-CHEMISTRY
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| 出版日期 | 2021-10-08 |
| 页码 | 5 |
| ISSN号 | 1674-7291 |
| 关键词 | medicinal plants dimeric sesquiterpenoids antimalarial agent structure-activity relationship |
| DOI | 10.1007/s11426-021-1124-x |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | In our long-term efforts searching for antimalarial agents from Chinese medicinal plants, seven novel dimeric sesquiterpenoids (1-7) with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp. brachystachys by solid data acquired by diverse methods. Among them, compound 3 with an EC50 value of 4.3 pM against the chloroquine-resistant Plasmodium falciparum is the most potent antimalarial agent reported hitherto, about 1,000-fold stronger than artemisinin. This article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class. |
| WOS关键词 | SESQUITERPENOID DIMERS ; CHLORANTHUS ; CHLORAHOLOLIDES ; BLOCKERS ; POTENT |
| 资助项目 | National Natural Science Foundation of China[21772212] ; Biological Resources Program, Chinese Academy of Sciences[ZSTH-032] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000705134700002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298436]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Dept Biochem & Mol Biol, Athens, GA 30602 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Zimbres, Flavia M.,Butler, Joshua H.,et al. Picomolar antimalarial agent from a Chinese medicinal plant[J]. SCIENCE CHINA-CHEMISTRY,2021:5. |
| APA | Zhou, Bin.,Zimbres, Flavia M..,Butler, Joshua H..,Xu, Cheng-Hui.,Haney, Reagan S..,...&Yue, Jian-Min.(2021).Picomolar antimalarial agent from a Chinese medicinal plant.SCIENCE CHINA-CHEMISTRY,5. |
| MLA | Zhou, Bin,et al."Picomolar antimalarial agent from a Chinese medicinal plant".SCIENCE CHINA-CHEMISTRY (2021):5. |
入库方式： OAI收割
来源：上海药物研究所
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