An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids
文献类型：期刊论文
| 作者 | Li, Jian1,2,3; Zhu, Yue2,4; Liu, Bo1,2; Tang, Feng1,2,3; Zheng, Xing4; Huang, Wei1,2,3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-10-01 |
| 卷号 | 23期号:19页码:7571-7574 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c02769 |
| 通讯作者 | Liu, Bo(boliu119@163.com) ; Huang, Wei(huangwei@simm.ac.cn) |
| 英文摘要 | An atom-economic N-to-C-directed solid-phase peptide synthesis is reported that uses benzyl (Bn) or (benzhydryl-carbamoyl)-methyl (BcM) esters of amino acids as the building blocks, which facilitate efficient hydrazinolysis, convenient conversion to acyl azide, and robust amidation with the next amino acid ester. This method is free of coupling reagents and free of protection on the side-chain OH, CO2H, CONH2, etc., therefore exhibiting a significantly improved atom economy compared to those of BOC- or Fmoc-based C-to-N-directed approaches. |
| WOS关键词 | CHEMICAL-SYNTHESIS ; LIGATION |
| 资助项目 | Natural Science Foundation of China (NSFC)[2187116] ; Natural Science Foundation of China (NSFC)[82003574] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000704710800049 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298445]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Bo; Huang, Wei |
| 作者单位 | 1.Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch, Dept Pharm,Grp Lead Compound,Hunan Prov Key Lab T, Hengyang 421001, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jian,Zhu, Yue,Liu, Bo,et al. An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids[J]. ORGANIC LETTERS,2021,23(19):7571-7574. |
| APA | Li, Jian,Zhu, Yue,Liu, Bo,Tang, Feng,Zheng, Xing,&Huang, Wei.(2021).An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids.ORGANIC LETTERS,23(19),7571-7574. |
| MLA | Li, Jian,et al."An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids".ORGANIC LETTERS 23.19(2021):7571-7574. |
入库方式： OAI收割
来源：上海药物研究所
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