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The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives

文献类型：期刊论文

作者Luo, Guoying1,2; Sun, Lanlan3; Li, Heng3,4; Chen, Jia1,2; He, Peilan3; Zhao, Liang1,2; Tang, Wei3,4; Qiu, Hongdeng1,2
刊名FITOTERAPIA
出版日期2021-11-01
卷号155页码:7
关键词Ionizing radiation Resveratrol Nitronyl nitroxide radical Radioprotection effects
ISSN号0367-326X
DOI10.1016/j.fitote.2021.105053
通讯作者Chen, Jia(jiachen@licp.cas.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要It is commonly known that radiotherapy is still a key modality for treatment of cancer. Though this effect is desirable during radiotherapy, it leads to radiotoxicity on normal healthy cells. In the present research, we designed, synthesized and analyzed a series of nitronyl nitroxide radical (NITR) spin-labeled resveratrol (RES) derivatives. The cytotoxicity of the newly synthesized substances was tested on Jurkat T cells. The derivatives were studied as reactive oxygen species (ROS) scavenger to protect ionizing radiation of Jurkat T cells upon 6 Gy X-irradiation. The experimental results revealed that compound 2 and 3 could significantly alleviate the damage of Jurkat T cells, as evidenced by decreasing ROS production and restoring the cell apoptosis. Further mechanism investigations indicated that the radioprotective effects of the novel derivatives were largely associated with modulating the expression of apoptotic proteins including cIAP-1, cIAP-2, cytochrome c, caspase-3 and caspase9. Based on the experimental result, we disclosed that the novel NITR spin-labeled RES derivatives exhibit the potential to be used as the novel radioprotective candidates to ameliorate the injury induced by ionizing radiation.
WOS关键词PHARMACOKINETICS ; CAMPTOTHECIN ; MECHANISMS ; EXPRESSION ; AMIFOSTINE ; CHEMISTRY ; RADIATION ; TOXICITY ; DESIGN ; DAMAGE
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000710100600002
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/298469]  
专题中国科学院上海药物研究所
通讯作者Chen, Jia; Tang, Wei
作者单位1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Luo, Guoying,Sun, Lanlan,Li, Heng,et al. The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives[J]. FITOTERAPIA,2021,155:7.
APA Luo, Guoying.,Sun, Lanlan.,Li, Heng.,Chen, Jia.,He, Peilan.,...&Qiu, Hongdeng.(2021).The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives.FITOTERAPIA,155,7.
MLA Luo, Guoying,et al."The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives".FITOTERAPIA 155(2021):7.

入库方式： OAI收割

来源：上海药物研究所

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