Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury
文献类型：期刊论文
| 作者 | Wu, Yong-Mei1,2; Shi, Qing3; Zhu, Peng-Fei1,2; Ma, Hai-Jian3; Cui, Shi-Chao2; Li, Jia1,2 ; Hou, Ai-Jun3; Li, Jing-Ya1,2
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| 刊名 | FASEB JOURNAL
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| 出版日期 | 2021-11-01 |
| 卷号 | 35期号:11页码:17 |
| 关键词 | acute kidney injury IKK/NF-kappa B inflammation macrophage PI3K/PDK1/Akt rhodomeroterpene |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.202100981RR |
| 通讯作者 | Li, Jia(jli@simm.ac.cn) ; Li, Jing-Ya(jyli@simm.ac.cn) |
| 英文摘要 | Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have not been proved successful in clinical trials. Macrophage infiltration into renal tissue promotes inflammatory responses that contribute to the pathogenesis of AKI. Suppression of renal tissue inflammatory responses is postulated to improve renal injury of patients and animals. Rhodomeroterpene (RMT) is a novel meroterpenoid isolated from the Rhododendron genus that was shown to exert anti-inflammatory action in vivo or in vitro in this study. We investigated the treatment effects of RMT on LPS-induced sepsis and two different AKI models. The results showed that pretreatment with RMT (30 mg kg(-1) d(-1) , ip, for 3 days) significantly inhibited acute inflammatory responses in LPS-induced septic mice. In both renal ischemia-reperfusion injury (I/R) and sepsis-induced AKI models, RMT (30 mg kg(-1) d(-1), ip, for 3 days) ameliorated renal function and injury and alleviated inflammation by reducing the infiltration of immune cells, including macrophages and neutrophils. Furthermore, our study demonstrated that RMT inhibits inflammatory responses in macrophages. The anti-inflammatory effects of RMT may be due to the inactivation of the IKK/NF-kappa B and PI3K/PDK1/Akt inflammatory signaling pathways in macrophages. Collectively, our findings indicate that RMT ameliorates renal injury and alleviates the renal inflammatory state in different AKI models, suggesting that RMT may be a potential agent for the treatment of AKI. |
| WOS关键词 | RHODODENDRON ; AKI ; MEROTERPENOIDS ; ACTIVATION ; CONTRIBUTE ; MECHANISM ; SEPSIS ; SYSTEM ; ROLES ; CELLS |
| 资助项目 | Ministry of Science and Technology Key Research Program[2016YFC1305505] ; Fudan University-Shanghai Institute of Materia Medica Cooperation Program[FU-SIMM20181011] ; Central Asian Drug Discovery and Development of ACS[CAM202001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000712009200032 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298668]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jia; Li, Jing-Ya |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.Fudan Univ, Sch Pharm, State Key Lab Med Neurobiol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yong-Mei,Shi, Qing,Zhu, Peng-Fei,et al. Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury[J]. FASEB JOURNAL,2021,35(11):17. |
| APA | Wu, Yong-Mei.,Shi, Qing.,Zhu, Peng-Fei.,Ma, Hai-Jian.,Cui, Shi-Chao.,...&Li, Jing-Ya.(2021).Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury.FASEB JOURNAL,35(11),17. |
| MLA | Wu, Yong-Mei,et al."Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury".FASEB JOURNAL 35.11(2021):17. |
入库方式： OAI收割
来源：上海药物研究所
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