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Photoactivatable nanogenerators of reactive species for cancer therapy

文献类型：期刊论文

作者Zheng, Xiaohua1; Jin, Yilan1,2,3; Liu, Xiao1; Liu, Tianqing4; Wang, Weiqi1,2,3; Yu, Haijun2,3
刊名BIOACTIVE MATERIALS
出版日期2021-12-01
卷号6期号:12页码:4301-4318
关键词Reactive oxygen species Reactive nitrogen species Alkyl radicals Carbon monoxide Phototherapy
DOI10.1016/j.bioactmat.2021.04.030
通讯作者Wang, Weiqi(wwq1990@ntu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness. Herein, we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy. First, we summarized the most widely explored reactive species, such as singlet oxygen, superoxide radical anion (O-2(center dot-)), nitric oxide ((NO)-N-center dot), carbon monoxide, alkyl radicals, and their corresponding secondary reactive species generated by interaction with other biological molecules. Then, we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation, followed by their anticancer effect, and the synergetic principles with other therapeutic modalities. This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.
WOS关键词GENERATING NADPH OXIDASES ; NITRIC-OXIDE DONORS ; PHOTODYNAMIC THERAPY ; FREE-RADICALS ; OXIDATIVE STRESS ; IN-VITRO ; CONTROLLABLE RELEASE ; SONODYNAMIC THERAPY ; OXYGEN ; ROS
资助项目National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[51873228] ; International Cooperation Project of Science and Technology Commission of Shanghai Municipality[20430711800] ; Scientific Research Foundation of Nantong University[135420623085]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000709332400003
出版者KEAI PUBLISHING LTD
源URL[http://119.78.100.183/handle/2S10ELR8/298671]  
专题新药研究国家重点实验室
通讯作者Wang, Weiqi; Yu, Haijun
作者单位1.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia
推荐引用方式
GB/T 7714		 Zheng, Xiaohua,Jin, Yilan,Liu, Xiao,et al. Photoactivatable nanogenerators of reactive species for cancer therapy[J]. BIOACTIVE MATERIALS,2021,6(12):4301-4318.
APA Zheng, Xiaohua,Jin, Yilan,Liu, Xiao,Liu, Tianqing,Wang, Weiqi,&Yu, Haijun.(2021).Photoactivatable nanogenerators of reactive species for cancer therapy.BIOACTIVE MATERIALS,6(12),4301-4318.
MLA Zheng, Xiaohua,et al."Photoactivatable nanogenerators of reactive species for cancer therapy".BIOACTIVE MATERIALS 6.12(2021):4301-4318.

入库方式： OAI收割

来源：上海药物研究所

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