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Concise synthesis of N-phosphorylated amides through three-component reactions

文献类型：期刊论文

作者Zhu, Yuan-Yuan1; Zhang, Tao2; Zhou, Linlin2; Yang, Shang-Dong1
刊名GREEN CHEMISTRY
出版日期2021-10-26
页码5
ISSN号1463-9262
DOI10.1039/d1gc03065e
通讯作者Yang, Shang-Dong(yangshd@lzu.edu.cn)
英文摘要N-Phosphorylated amides continue to be an unparalleled asset for the development of pharmaceutical molecules, and the importance of this framework has inspired researchers to look for concise and efficient methods for the synthesis of this unit. In this work, a new strategy was developed in which a one-pot synthesis of N-phosphorylated amides was achieved by a three-component reaction with carboxylic acids, phosphorus chlorides and azides under mild reaction conditions. To our knowledge, this is the first study in which this framework was constructed through a multicomponent reaction, which is innovative, efficient and economical.
WOS关键词PHOTO-ARBUZOV REARRANGEMENTS ; MULTICOMPONENT REACTIONS ; CYCLOPHOSPHAMIDE ANALOG ; STAUDINGER LIGATION ; PHOSMIDOSINE ; PEPTIDES ; ACIDS ; MECHANISM ; SULINDAC ; BENZYL
资助项目NSFC[21532001] ; International Joint Research Centre for Green Catalysis and Synthesis[2016B01017] ; Lanzhou University
WOS研究方向Chemistry ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000715420900001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/298695]  
专题中国科学院上海药物研究所
通讯作者Yang, Shang-Dong
作者单位1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Yuan-Yuan,Zhang, Tao,Zhou, Linlin,et al. Concise synthesis of N-phosphorylated amides through three-component reactions[J]. GREEN CHEMISTRY,2021:5.
APA Zhu, Yuan-Yuan,Zhang, Tao,Zhou, Linlin,&Yang, Shang-Dong.(2021).Concise synthesis of N-phosphorylated amides through three-component reactions.GREEN CHEMISTRY,5.
MLA Zhu, Yuan-Yuan,et al."Concise synthesis of N-phosphorylated amides through three-component reactions".GREEN CHEMISTRY (2021):5.

入库方式： OAI收割

来源：上海药物研究所

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