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Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy

文献类型：期刊论文

作者Xu, Xiaoxuan1,2,3; Wu, Yao1,2; Qian, Xindi1,2,3; Wang, Yuqi1,2; Wang, Jiaoying1,2; Li, Jie1,2; Li, Yaping1,2,3; Zhang, Zhiwen1,2,3,4
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2021-11-10
页码25
关键词cancer therapy drug delivery extracellular matrix nanomedicine tumor penetration
ISSN号2192-2640
DOI10.1002/adhm.202101428
通讯作者Zhang, Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要The dense and heterogeneous physical network of the extracellular matrix (ECM) in tumors represents a formidable barrier that limits intratumor drug delivery and the therapeutic efficacy of many anticancer therapies. Here, the two major nanomedicine strategies to circumvent intratumor ECM barriers: regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM are summarized. Nanomedicines can be rationally regulated by optimizing physiochemical properties or designed with biomimetic features to promote ECM permeation capability. Meanwhile, they can also be designed to remodel the ECM by modulating signaling pathways or destroying the components and architecture of the ECM via chemical, biological, or physical treatments. These efforts produce profound improvements in intratumor drug delivery and anticancer efficacy. Moreover, to aid in their anticancer efficacy, feasible approaches for improving ECM-circumventing nanomedicines are proposed.
WOS关键词TUMOR-TARGETING EFFICIENCY ; PANCREATIC-CANCER ; IN-VIVO ; LUNG METASTASIS ; DRUG-DELIVERY ; NANOPARTICLES ; PENETRATION ; MICROENVIRONMENT ; BREAST ; CELL
资助项目National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000716812100001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/298704]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharm, 19A Yuqian Rd, Beijing 100049, Peoples R China
4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Xiaoxuan,Wu, Yao,Qian, Xindi,et al. Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2021:25.
APA Xu, Xiaoxuan.,Wu, Yao.,Qian, Xindi.,Wang, Yuqi.,Wang, Jiaoying.,...&Zhang, Zhiwen.(2021).Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,25.
MLA Xu, Xiaoxuan,et al."Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy".ADVANCED HEALTHCARE MATERIALS (2021):25.

入库方式： OAI收割

来源：上海药物研究所

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