Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection
文献类型：期刊论文
| 作者 | Zhang, Shihai1,3; Pei, Rongjuan6; Li, Meixia3,4; Su, Haixia4,5; Sun, Hao6; Ding, Yaqi3,4; Su, Minbo4,5; Huang, Chunfan2,3; Chen, Xia3,4; Du, Zhenyun3,4 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2022 |
| 卷号 | 275页码:8 |
| 关键词 | COVID-19 SARS-CoV-2 Angiotensin converting enzyme 2 (ACE2) 3CL protease Ecklonia kurome Okam Polysaccharide |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2021.118779 |
| 通讯作者 | Xu, Yechun(ycxu@simm.ac.cn) ; Chen, Xinwen(chenxw@wh.iov.cn) ; Zhang, Bo(zhangbo@wh.iov.cn) ; Ding, Kan(dingkan@simm.ac.cn) |
| 英文摘要 | Previous researches suggested that polysaccharides from brown algae had anti-virus activity. We hypothesized that nature polysaccharide from marine plants might have the effect on anti-SARS-CoV-2 activity. By high throughput screening to target 3CLpro enzyme using polysaccharides library, we discover a crude polysaccharide 375 from seaweed Ecklonia kurome blocked 3CLpro enzymatic activity and shows good anti-SARS-CoV-2 infection activity in cell. Further, we show that homogeneous polysaccharide 37502 from the 375 may bind to 3CLpro well and disturb spike protein binding to ACE2 receptor. The structure characterization uncovers that 37502 is alginate. These results imply that the bioactivities of 375 on SARS-CoV-2 may target multiple key molecules implicated in the virus infection and replication. The above results suggest that 375 may be a potential drug candidate against SARS-CoV-2. |
| WOS关键词 | ALGINATE ; SARS ; ACID |
| 资助项目 | National Key Research and Development Program of China ; Ministry of Science and Technology of the People's Republic of China[2019YFC1711-000] ; Key New Drug Creation and Manufacturing Program[2019ZX09735001] ; COVID-19 Emergency Research Project by Zhejiang University[2020XGZX080] ; Shanghai Municipal Science and Technology Commission Major Project |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000712466000011 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298756]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Yechun; Chen, Xinwen; Zhang, Bo; Ding, Kan |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China 2.Nanjing Univ Chinese Med, Coll Pharm, 138 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China 3.Glycochem & Glycobiol Lab, Key Lab Receptor Res, Nanjing, Peoples R China 4.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 5.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shihai,Pei, Rongjuan,Li, Meixia,et al. Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection[J]. CARBOHYDRATE POLYMERS,2022,275:8. |
| APA | Zhang, Shihai.,Pei, Rongjuan.,Li, Meixia.,Su, Haixia.,Sun, Hao.,...&Ding, Kan.(2022).Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection.CARBOHYDRATE POLYMERS,275,8. |
| MLA | Zhang, Shihai,et al."Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection".CARBOHYDRATE POLYMERS 275(2022):8. |
入库方式： OAI收割
来源：上海药物研究所
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