Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics
文献类型：期刊论文
| 作者 | Cheng, Chen; Yu, Xuan |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2021-10-01 |
| 卷号 | 22期号:20页码:27 |
| 关键词 | antiseptic actions Chinese herbal medicines material basis Qingwen Baidu decoction Shengfu injection Shengmai sepsis Xuanbai Chengqi decoction XueBiJing injection |
| DOI | 10.3390/ijms222011078 |
| 通讯作者 | Cheng, Chen(chengchen@simm.ac.cn) |
| 英文摘要 | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on the timely and appropriate administration of antimicrobials and supportive therapies, but the search for pharmacotherapies modulating the host response has been unsuccessful. Chinese herbal medicines, i.e., Chinese patent medicines, Chinese herbal prescriptions, and single Chinese herbs, play an important role in the treatment of sepsis through multicomponent, multipathway, and multitargeting abilities and have been officially recommended for the management of COVID-19. Chinese herbal medicines have therapeutic actions promising for the treatment of sepsis; basic scientific research on these medicines is increasing. However, the material bases of most Chinese herbal medicines and their underlying mechanisms of action have not yet been fully elucidated. This review summarizes the current studies of Chinese herbal medicines used for the treatment of sepsis in terms of clinical efficacy and safety, pharmacological activity, phytochemistry, bioactive constituents, mechanisms of action, and pharmacokinetics, to provide an important foundation for clarifying the pathogenesis of sepsis and developing novel antisepsis drugs based on Chinese herbal medicines. |
| WOS关键词 | ACUTE LUNG INJURY ; ISCHEMIA-REPERFUSION INJURY ; METABOLITE COMPOUND K ; ACUTE KIDNEY INJURY ; KAPPA-B INHIBITORS ; SHEN-FU INJECTION ; XUEBIJING INJECTION ; LIQUID-CHROMATOGRAPHY ; CHEMICAL-CONSTITUENTS ; RAT PLASMA |
| 资助项目 | National Natural Science Foundation of China[82074176] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000715246200001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298768]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Chen |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Chen,Yu, Xuan. Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021,22(20):27. |
| APA | Cheng, Chen,&Yu, Xuan.(2021).Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(20),27. |
| MLA | Cheng, Chen,et al."Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22.20(2021):27. |
入库方式： OAI收割
来源：上海药物研究所
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