Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics
文献类型：期刊论文
| 作者 | Tong, Pei-Hong1,2; Zhu, Ling1,2; Zang, Yi3 ; Li, Jia3; He, Xiao-Peng1,2; James, Tony D.4,5
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| 刊名 | CHEMICAL COMMUNICATIONS
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| 出版日期 | 2021-11-16 |
| 卷号 | 57期号:91页码:12098-12110 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d1cc05157a |
| 通讯作者 | Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; James, Tony D.(t.d.james@bath.ac.uk) |
| 英文摘要 | Biomacromolecular drugs have become an important class of therapeutic agents for the treatment of human diseases. Considering their high propensity for being degraded in the human body, the choice of an appropriate delivery system is key to ensure the therapeutic efficacy of biomacromolecular drugs in vivo. As an emerging class of supramolecular "host" materials, metal-organic frameworks (MOFs) exhibit advantages in terms of the tunabdity of pore size, encapsulation efficiency, controllable drug release, simplicity in surface functionalization and good biocompatibility. As a result, MOF-based host-guest systems have been extensively developed as a new class of flexible and powerful platform for the delivery of therapeutic biomacromolecules. In this review, we summarize current research progress in the synthesis of MOFs as delivery materials for a variety of biomacromolecules. Firstly, we briefly introduce the advances made in the use of biomacromolecular drugs for disease therapy and the types of commonly used clinical delivery systems. We then describe the advantages of using MOFs as delivery materials. Secondly, the strategies for the construction of MOF-encapsulated biomacromolecules (Biomacromolecules@MOFs) and the release mechanisms of the therapeutics are categorized. Thirdly, the application of MOFs to deliver different types of biomacromolecules (e.g., antigens/antibodies, enzymes, therapeutic proteins, DNA/RNA, polypeptides, and polysaccharides) for the treatment of various human diseases based on immunotherapy, gene therapy, starvation therapy and oxidation therapy is summarized. Finally, the remaining challenges and available opportunities for MOFs as drug delivery systems are outlined, which we anticipate will encourage additional research efforts directed towards developing Biomacromolecules@MOFs systems for biomedical applications. |
| WOS关键词 | POOLED SIRNAS ; CO-DELIVERY ; CANCER ; THERAPY ; NANOPARTICLES ; STRATEGY ; VECTORS ; TUMOR ; RESISTANCE ; CHALLENGES |
| 资助项目 | National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; international cooperation program of Shanghai Science and Technology Committee[17520750100] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000712543700001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298784]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jia; He, Xiao-Peng; James, Tony D. |
| 作者单位 | 1.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 5.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, Pei-Hong,Zhu, Ling,Zang, Yi,et al. Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics[J]. CHEMICAL COMMUNICATIONS,2021,57(91):12098-12110. |
| APA | Tong, Pei-Hong,Zhu, Ling,Zang, Yi,Li, Jia,He, Xiao-Peng,&James, Tony D..(2021).Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics.CHEMICAL COMMUNICATIONS,57(91),12098-12110. |
| MLA | Tong, Pei-Hong,et al."Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics".CHEMICAL COMMUNICATIONS 57.91(2021):12098-12110. |
入库方式： OAI收割
来源：上海药物研究所
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