M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
文献类型：期刊论文
| 作者 | Wang,Yuqi1,2; Gong,Xiang2; Li,Jie2; Wang,Hong2; Xu,Xiaoxuan2; Wu,Yao2; Wang,Jiaoying2; Wang,Siling1; Li,Yaping2 ; Zhang,Zhiwen2,3
|
| 刊名 | Journal of Nanobiotechnology
 |
| 出版日期 | 2021-11-27 |
| 卷号 | 19期号:1 |
| 关键词 | Cancer stem cells Macrophage Microvesicle Nanoparticles Cabazitaxel |
| DOI | 10.1186/s12951-021-01143-5 |
| 通讯作者 | Wang,Siling(wangslsy@163.com) ; Li,Yaping(ypli@simm.ac.cn) ; Zhang,Zhiwen(zwzhang0125@simm.ac.cn) |
| 英文摘要 | AbstractCancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors. Moreover, M-CFN treatment profoundly eliminated aldehyde dehydrogenase (ALDH)-expressing CSCs in 4T1 and MCF-7 tumors, produced notable depression of tumor growth and caused 93.86% suppression of lung metastasis in 4T1 models. Therefore, the M2 macrophage microvesicle-inspired nanovehicle provides an encouraging strategy to penetrate the tumor tissues and access these insult cells in tumors for effective cancer therapy.Graphical Abstract |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12951-021-01143-5 |
| 出版者 | BioMed Central |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298803]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang,Siling; Li,Yaping; Zhang,Zhiwen |
| 作者单位 | 1.Shenyang Pharmaceutical University; School of Pharmacy 2.Chinese Academy of Sciences; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica 3.Yantai Institute of Materia Medica; Yantai Key Laboratory of Nanomedicine & Advanced Preparations |
| 推荐引用方式 GB/T 7714 | Wang,Yuqi,Gong,Xiang,Li,Jie,et al. M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors[J]. Journal of Nanobiotechnology,2021,19(1). |
| APA | Wang,Yuqi.,Gong,Xiang.,Li,Jie.,Wang,Hong.,Xu,Xiaoxuan.,...&Zhang,Zhiwen.(2021).M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors.Journal of Nanobiotechnology,19(1). |
| MLA | Wang,Yuqi,et al."M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors".Journal of Nanobiotechnology 19.1(2021). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。