Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy
文献类型：期刊论文
| 作者 | Shi,Junyu2; Zhang,Yi2,3; Zhang,Xiaomeng2; Chen,Ruiying2; Wei,Jianxu2; Hou,Jiazhen3; Wang,Bing3; Lai,Hongchang2; Huang,Yongzhuo1,3,4,5
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| 刊名 | Journal of Nanobiotechnology
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| 出版日期 | 2021-12-20 |
| 卷号 | 19期号:1 |
| 关键词 | Resveratrol Macrophage Periodontitis Liposome Immune microenvironment Local delivery |
| DOI | 10.1186/s12951-021-01175-x |
| 通讯作者 | Lai,Hongchang(laihongchang@sjtu.edu.cn) ; Huang,Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | AbstractBackgroundPeriodontitis is a complicated inflammatory disease that damages the tooth-supporting tissues, with limited pharmacotherapy?available. Macrophage-targeting therapy is promising for inflammatory diseases. Resveratrol (RSV), a nonflavonoid polyphenol, is known for its anti-inflammatory and immunomodulatory effects. However, its medical application is limited by its poor stability and water-solubility, as well as its low bioavailability.ResultA therapeutic resveratrol-loaded liposomal system (Lipo-RSV) was developed to treat periodontitis. The physical properties of Lipo-RSV and its ability to regulate macrophages were investigated. The results showed that Lipo-RSV had good biocompatibility and could re-educate the inflammatory macrophages from M1- to M2-like phenotype through activating p-STAT3 and downregulating p-STAT1. Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-κB signal and inflammasomes, thereby reducing the?pro-inflammatory cytokines IL-1β, IL-6, and TNF-α.ConclusionThese results revealed that Lipo-RSV could be a potential therapeutic system for the antibiotic-free treatment for periodontal diseases.Graphical Abstract |
| 语种 | 英语 |
| 出版者 | BioMed Central |
| WOS记录号 | BMC:10.1186/S12951-021-01175-X |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298807]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lai,Hongchang; Huang,Yongzhuo |
| 作者单位 | 1.NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients 2.Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Department of Implant Dentistry 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences; State Key Laboratory of Drug Research 4.Zhongshan Institute for Drug Discovery, SIMM, CAS 5.Taizhou University, School of Advanced Study, Institute of Natural Medicine and Health Product |
| 推荐引用方式 GB/T 7714 | Shi,Junyu,Zhang,Yi,Zhang,Xiaomeng,et al. Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy[J]. Journal of Nanobiotechnology,2021,19(1). |
| APA | Shi,Junyu.,Zhang,Yi.,Zhang,Xiaomeng.,Chen,Ruiying.,Wei,Jianxu.,...&Huang,Yongzhuo.(2021).Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy.Journal of Nanobiotechnology,19(1). |
| MLA | Shi,Junyu,et al."Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy".Journal of Nanobiotechnology 19.1(2021). |
入库方式： OAI收割
来源：上海药物研究所
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