A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles
文献类型:期刊论文
作者 | Qi, Jingjing1,2; Liu, Sixiu2,3; Seydimemet, Mengnisa1,2; Wang, Xuan2; Lu, Xiaojie1,2,3![]() |
刊名 | BIOCONJUGATE CHEMISTRY
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出版日期 | 2021-11-17 |
卷号 | 32期号:11页码:2290-2294 |
ISSN号 | 1043-1802 |
DOI | 10.1021/acs.bioconjchem.1c00427 |
通讯作者 | Wang, Xuan(wangxuan2@simm.ac.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn) |
英文摘要 | DNA-encoded library (DEL) technology provided a powerful screening platform for identifying potential bioactive small molecules with high affinity to biologically interesting targets. Essential to a successful DEL campaign are the drug-like small molecular moieties of DNA-encoded libraries with expanded chemical space. Our laboratory has been working on developing and producing novel DNA-encoded libraries that complement current reported DELs. Herein, we demonstrated a general set of DNA-compatible reactions that enable the preparation of pyrrole-based DNA-encoded libraries in which the DNA tags are linked to the N position of the pyrrole central core. Further diversification could be rapidly incorporated into the pyrrole scaffold by robust iodination and Suzuki coupling reactions. |
资助项目 | NSFC[21877117] ; NSFC[91953203] ; NSFC[21907103] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-005] ; Shanghai Commission of Science and Technology[18431907100] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000721347100002 |
出版者 | AMER CHEMICAL SOC |
源URL | [http://119.78.100.183/handle/2S10ELR8/298964] ![]() |
专题 | 新药研究国家重点实验室 |
通讯作者 | Wang, Xuan; Lu, Xiaojie |
作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Qi, Jingjing,Liu, Sixiu,Seydimemet, Mengnisa,et al. A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles[J]. BIOCONJUGATE CHEMISTRY,2021,32(11):2290-2294. |
APA | Qi, Jingjing,Liu, Sixiu,Seydimemet, Mengnisa,Wang, Xuan,&Lu, Xiaojie.(2021).A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles.BIOCONJUGATE CHEMISTRY,32(11),2290-2294. |
MLA | Qi, Jingjing,et al."A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles".BIOCONJUGATE CHEMISTRY 32.11(2021):2290-2294. |
入库方式: OAI收割
来源:上海药物研究所
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