Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source
文献类型：期刊论文
| 作者 | Cheng, Tai-Jin1,2; Chen, Jun-Jie1; Wu, Peng3; Xu, Hui1; Dai, Hui-Xiong1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-11-05 |
| 卷号 | 23期号:21页码:8505-8509 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c03223 |
| 通讯作者 | Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | We report herein a copper-mediated ortho-C-H amination of anilines using oxalamide as the directing group and DMF as the amination reagent. This protocol tolerates various functional groups and shows good heterocyclic compatibility. Late-stage dimethylamination of drugs demonstrated the synthetic practicality of the protocol. Mechanistic experiments indicate that a radical pathway may be involved in the reaction. |
| WOS关键词 | (HETERO)ARYL CHLORIDES ; CATALYZED AMINATION ; ARYL CHLORIDES ; CYANATION ; N,N-DIMETHYLFORMAMIDE ; BONDS ; FUNCTIONALIZATION ; ALKYNYLATION ; FORMAMIDES ; AMMONIA |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[21772211] ; National Natural Science Foundation of China[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; China Postdoctoral Science Foundation[2019M662854] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000716793100075 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298970]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Dai, Hui-Xiong |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Tai-Jin,Chen, Jun-Jie,Wu, Peng,et al. Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source[J]. ORGANIC LETTERS,2021,23(21):8505-8509. |
| APA | Cheng, Tai-Jin,Chen, Jun-Jie,Wu, Peng,Xu, Hui,&Dai, Hui-Xiong.(2021).Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source.ORGANIC LETTERS,23(21),8505-8509. |
| MLA | Cheng, Tai-Jin,et al."Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source".ORGANIC LETTERS 23.21(2021):8505-8509. |
入库方式： OAI收割
来源：上海药物研究所
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