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Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines

文献类型：期刊论文

作者Liu, Jie2; Wang, Hong-da2; Yang, Fei-fei2; Chen, Bo-xue2; Li, Xue2; Huang, Qing-xia3; Li, Jing3; Li, Xiang-yan3; Li, Zheng1,2; Yu, He-shui1,2
刊名CARBOHYDRATE POLYMERS
出版日期2022-02-01
卷号277页码:10
关键词Panax Polysaccharide Oligosaccharide spectrum Untargeted metabolomics Cardiomyocyte protection
ISSN号0144-8617
DOI10.1016/j.carbpol.2021.118867
通讯作者Guo, De-an(daguo@simm.ac.cn) ; Yang, Wen-zhi(wzyang0504@tjutcm.edu.cn)
英文摘要The role of polysaccharides in quality control of ginseng is underestimated. Large-scale comparison on the polysaccharides of Panax ginseng (PG), P. quinquefolius (PQ), P. notoginseng (PN), Red ginseng (RG), P. japonicus (ZJS), and P. japonicus var. major (ZZS), was performed by both chemical and biological approaches. Holistic fingerprinting at polysaccharide and the hydrolyzed oligosaccharide and monosaccharide levels utilized various chromatography methods, while OGD and OGD/R models on H9c2 cells were introduced to evaluate the protective effects on cell viability and mitochondrial function. Polysaccharides from six ginseng species exhibited remarkable content difference (RG > PG/ZZS/ZJS/PQ > PN), but weak differentiations in molecular weight distribution and oligosaccharide profiles, while Glc and GalA were richer for monosaccharide compositions of PG and RG polysaccharides, respectively. RG polysaccharides (25/50/100 mu g/mL) showed significant cardiomyocyte protection by regulating mitochondrial functions. These new evidences may provide support for the supplementary role of polysaccharides in quality control of ginseng.
WOS关键词PANAX-GINSENG ; METABOLISM
资助项目National Natural Science Foundation of China[81872996] ; National Natural Science Foundation of China[82130111] ; Natural Science Foundation of Tianjin of China[20JCYBJC00060] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-D-202002]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000720837300001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/298982]  
专题中国科学院上海药物研究所
通讯作者Guo, De-an; Yang, Wen-zhi
作者单位1.Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin 301617, Peoples R China
2.Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin Key Lab TCM Chem & Anal, 10 Poyanghu Rd, Tianjin 301617, Peoples R China
3.Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun 130117, Peoples R China
4.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Jie,Wang, Hong-da,Yang, Fei-fei,et al. Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines[J]. CARBOHYDRATE POLYMERS,2022,277:10.
APA Liu, Jie.,Wang, Hong-da.,Yang, Fei-fei.,Chen, Bo-xue.,Li, Xue.,...&Yang, Wen-zhi.(2022).Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines.CARBOHYDRATE POLYMERS,277,10.
MLA Liu, Jie,et al."Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines".CARBOHYDRATE POLYMERS 277(2022):10.

入库方式： OAI收割

来源：上海药物研究所

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