The double faced role of xanthine oxidoreductase in cancer
文献类型：期刊论文
| 作者 | Chen, Man-Man1,2; Meng, Ling-Hua1,2
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2021-11-22 |
| 页码 | 10 |
| 关键词 | xanthine oxidoreductase (XOR) ROS uric acid cancer therapy |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-021-00800-7 |
| 通讯作者 | Meng, Ling-Hua(lhmeng@simm.ac.cn) |
| 英文摘要 | Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. It also produces reactive oxygen species (ROS) during the catalytic process. The enzyme is generally recognized as a drug target for the therapy of gout and hyperuricemia. The catalytic products uric acid and ROS act as antioxidants or oxidants, respectively, and are involved in pro/anti-inflammatory actions, which are associated with various disease manifestations, including metabolic syndrome, ischemia reperfusion injury, cardiovascular disorders, and cancer. Recently, extensive efforts have been devoted to understanding the paradoxical roles of XOR in tumor promotion. Here, we summarize the expression of XOR in different types of cancer and decipher the dual roles of XOR in cancer by its enzymatic or nonenzymatic activity to provide an updated understanding of the mechanistic function of XOR in cancer. We also discuss the potential to modulate XOR in cancer therapy. |
| WOS关键词 | TUMOR LYSIS SYNDROME ; SERUM URIC-ACID ; OXIDATIVE STRESS ; OXIDASE INHIBITORS ; PROSTATE-CANCER ; MAMMARY-GLAND ; BREAST-CANCER ; SUPEROXIDE-DISMUTASE ; RAT MODEL ; CELL |
| 资助项目 | National Natural Science Foundation of China[81773760] ; National Natural Science Foundation of China[81973345] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000721428700004 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299000]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Meng, Ling-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Man-Man,Meng, Ling-Hua. The double faced role of xanthine oxidoreductase in cancer[J]. ACTA PHARMACOLOGICA SINICA,2021:10. |
| APA | Chen, Man-Man,&Meng, Ling-Hua.(2021).The double faced role of xanthine oxidoreductase in cancer.ACTA PHARMACOLOGICA SINICA,10. |
| MLA | Chen, Man-Man,et al."The double faced role of xanthine oxidoreductase in cancer".ACTA PHARMACOLOGICA SINICA (2021):10. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。