Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings
文献类型：期刊论文
| 作者 | Wang, Zhen-Yu2; Ma, Biao1; Xu, Hui1; Wang, Xing1; Zhang, Xu2; Dai, Hui-Xiong1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-11-05 |
| 卷号 | 23期号:21页码:8291-8295 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c03048 |
| 通讯作者 | Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | Herein, we report the arylation, alkylation, and alkenylation of aryl ketones via a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. The use of the pyridine-oxazoline ligand is the key to the cleavage of the unstrained C-C bond. The late-stage arylation of aryl ketones derived from drugs and natural products demonstrated the synthetic utility of this protocol. |
| WOS关键词 | CARBON-CARBON BONDS ; C-H BONDS ; DIRECTED CLEAVAGE ; CROSS-COUPLINGS ; ACTIVATION ; FUNCTIONALIZATION ; ETHERS ; CARBOACYLATION ; OLEFINS ; KETONES |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[21772211] ; National Natural Science Foundation of China[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, the Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; China Postdoctoral Science Foundation[2019M662854] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000716793100035 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299012]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Dai, Hui-Xiong |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhen-Yu,Ma, Biao,Xu, Hui,et al. Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings[J]. ORGANIC LETTERS,2021,23(21):8291-8295. |
| APA | Wang, Zhen-Yu,Ma, Biao,Xu, Hui,Wang, Xing,Zhang, Xu,&Dai, Hui-Xiong.(2021).Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings.ORGANIC LETTERS,23(21),8291-8295. |
| MLA | Wang, Zhen-Yu,et al."Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings".ORGANIC LETTERS 23.21(2021):8291-8295. |
入库方式： OAI收割
来源：上海药物研究所
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