NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody
文献类型：期刊论文
| 作者 | Shi, Hui1,2; Huttad, Lakshmi Vageesh3; Tan, Mingdian3; Liu, Hongguang1; Chua, Mei-Sze3; Cheng, Zhen2,4,5; So, Samuel3 |
| 刊名 | RSC MEDICINAL CHEMISTRY
 |
| 出版日期 | 2021-11-23 |
| 页码 | 8 |
| DOI | 10.1039/d1md00313e |
| 通讯作者 | Chua, Mei-Sze(mchua@stanford.edu) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Liver cancer, of which hepatocellular carcinoma (HCC) is the most common form, is one of the most lethal cancers worldwide. The five-year survival rate for HCC is below 9%, which can be attributed to late diagnosis and limited treatment options at the late stage. Therefore, safe and efficient imaging strategies are urgently needed to facilitate HCC diagnosis and stage evaluation. The development of the second near infrared window (NIR-II, 1000-1700 nm) fluorescence imaging offers the advantages of enhanced resolutions, deeper penetration depth, and less autofluorescence compared to traditional NIR-I window (700-900 nm) imaging. Herein, an HCC targeted NIR-II fluorescent probe, GPC-ICG, was developed by labelling a humanized anti-GPC3 monoclonal antibody with indocyanine green (ICG). Compared to the negative control IgG-ICG probe, the GPC3-ICG probe demonstrated specific GPC3 targeting capability in vitro. And for GPC3 positive Huh-7 tumor bearing mice, the GPC3-ICG probe specifically accumulated in subcutaneous xenografts, with a tumor-background ratio (TBR) of up to 3. The NIR-II imaging of mice organs ex vivo also indicated that GPC3-ICG specifically targeted Huh-7 tumor tissue. Overall, GPC3-ICG is a promising NIR-II probe for GPC3 targeted imaging of HCC. |
| WOS关键词 | INDOCYANINE GREEN ; LIVER-CANCER ; PRECISION DIAGNOSIS ; GLYPICAN-3 ; EXPRESSION ; PROTEIN ; MARKER ; GPC3 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000723236400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299027]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chua, Mei-Sze; Cheng, Zhen |
| 作者单位 | 1.Northeastern Univ, Coll Life & Hlth Sci, Inst Mol Med, Shenyang 110000, Peoples R China 2.Stanford Univ, Dept Radiol & Bio X Program, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA 3.Stanford Univ, Asian Liver Ctr, Sch Med, Dept Surg, Stanford, CA 94305 USA 4.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Hui,Huttad, Lakshmi Vageesh,Tan, Mingdian,et al. NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody[J]. RSC MEDICINAL CHEMISTRY,2021:8. |
| APA | Shi, Hui.,Huttad, Lakshmi Vageesh.,Tan, Mingdian.,Liu, Hongguang.,Chua, Mei-Sze.,...&So, Samuel.(2021).NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody.RSC MEDICINAL CHEMISTRY,8. |
| MLA | Shi, Hui,et al."NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody".RSC MEDICINAL CHEMISTRY (2021):8. |
入库方式： OAI收割
来源：上海药物研究所
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