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New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata

文献类型：期刊论文

作者Lin, Na1,2,3; Li, Heng3; Wang, Jian-Rong3; Tang, Wei3; Zheng, Ming-Yue3; Wang, Hong1,2; Jiang, Cheng-Shi5; Guo, Yue-Wei1,2,3,4
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2022
卷号40期号:1页码:28-38
关键词Sinularia nanolobata Cembranoids X-ray diffraction Configuration determination Natural products
ISSN号1001-604X
DOI10.1002/cjoc.202100597
通讯作者Wang, Hong(hongw@zjut.edu.cn) ; Jiang, Cheng-Shi(bio_jiangcs@ujn.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Comprehensive Summary In the present study, nine new cembrane-type diterpenoids, namely ximaonanolobatins A-I (1-9), together with six related known analogs (10-15) and four known tetraprenylated alkaloids malonganenones D, E, H, and K (16-19) were isolated from the soft coral Sinularia nanolobata collected off the Ximao Island in the South China Sea. The structures of 1-9 were robustly established by a combination of detailed spectroscopic analyses, chemical reactions, quantum mechanical (QM)-NMR methods, biogenetic consideration, and the comparison with those literature data. The absolute configuration of 1 was confirmed by X-ray diffraction analysis, and the absolute configuration of 2 was determined by QM-NMR calculations and chemical transformation. In addition, the absolute configuration of 3 was determined using the modified Mosher's method. All these isolates were evaluated for their anti-inflammatory and anti-tumor activities. The results showed that only compound 15 exhibited potential anti-inflammatory effect against LPS-induced TNF-alpha release in RAW264.7 macrophages with an IC50 value of 12.6 mu mol/L.
WOS关键词TETRAPRENYLATED ALKALOIDS ; CONSTITUENTS ; TERPENOIDS ; METABOLITES ; GROWTH
资助项目National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000723114400001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/299033]  
专题新药研究国家重点实验室
通讯作者Wang, Hong; Jiang, Cheng-Shi; Guo, Yue-Wei
作者单位1.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China
2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Binhai East Rd 198, Yantai 264000, Shandong, Peoples R China
5.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Na,Li, Heng,Wang, Jian-Rong,et al. New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata[J]. CHINESE JOURNAL OF CHEMISTRY,2022,40(1):28-38.
APA Lin, Na.,Li, Heng.,Wang, Jian-Rong.,Tang, Wei.,Zheng, Ming-Yue.,...&Guo, Yue-Wei.(2022).New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata.CHINESE JOURNAL OF CHEMISTRY,40(1),28-38.
MLA Lin, Na,et al."New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata".CHINESE JOURNAL OF CHEMISTRY 40.1(2022):28-38.

入库方式： OAI收割

来源：上海药物研究所

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