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Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum

文献类型：期刊论文

作者Li, Jin-Feng1,2,3; Zeng, Yan-Bo1,3; Li, Wang-Sheng2,4; Luo, Hui4; Zhang, Hai-Yan2; Guo, Yue-Wei2,5
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2022
卷号40期号:1页码:79-90
关键词Sarcophyton glaucum Cembranoids Configuration determination X-ray diffraction NMR spectroscopy
ISSN号1001-604X
DOI10.1002/cjoc.202100564
通讯作者Zeng, Yan-Bo(zengyanbo@itbb.org.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Ten new cembrane-type diterpenoids, namely xishaglaucumins A-J (1-10), along with ten known related ones (11-20), have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) methods, X-ray diffraction analysis, chemical methods and comparison with the reported data in the literature. The absolute configuration of new compounds 1, 5 and known compounds 11, 12, 16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu K alpha (lambda = 1.5417 angstrom). In in vitro bioassay, compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells. [GRAPHICS]
WOS关键词ANTI-TUMOR-PROMOTER ; MARINE TERPENES ; METABOLITES ; DITERPENES ; CHEMISTRY
资助项目National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[41776093] ; National Key Research and Development Program of China[2018YFC0310903] ; Key Research and Development Project of Hainan Province[ZDYF2021SHFZ107] ; Financial Fund of the Ministry of Agriculture and Rural Affairs, P. R. China[NFZX2021] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000722182500001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/299039]  
专题新药研究国家重点实验室
通讯作者Zeng, Yan-Bo; Guo, Yue-Wei
作者单位1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
3.Hebei Agr Univ, Ocean Coll, Qinhuangdao 066000, Hebei, Peoples R China
4.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang Res & Dev Marine Microbial Reso, Zhanjiang 524023, Guangdong, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jin-Feng,Zeng, Yan-Bo,Li, Wang-Sheng,et al. Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum[J]. CHINESE JOURNAL OF CHEMISTRY,2022,40(1):79-90.
APA Li, Jin-Feng,Zeng, Yan-Bo,Li, Wang-Sheng,Luo, Hui,Zhang, Hai-Yan,&Guo, Yue-Wei.(2022).Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum.CHINESE JOURNAL OF CHEMISTRY,40(1),79-90.
MLA Li, Jin-Feng,et al."Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum".CHINESE JOURNAL OF CHEMISTRY 40.1(2022):79-90.

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来源：上海药物研究所

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