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Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis

文献类型：期刊论文

作者Chen, Hao-Wei1,2; Jiang, Chun-Xiao1,2; Li, Jiyang1; Li, Na2; Zang, Yi3; Wu, Xi-Ying1,4; Chen, Wen-Xue5; Xiong, Juan1; Li, Jia; Hu, Jin-Feng1,2
刊名RSC ADVANCES
出版日期2021-12-14
卷号11期号:63页码:39781-39789
DOI10.1039/d1ra08377e
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要A number of previously undescribed (1-7) and structurally related known (8-17) isobenzofuran-type polyketides were obtained from the fermentation of Penicillium commune P-4-1, an endophytic fungus isolated from the fresh trunk bark of the critically endangered conifer Abies beshanzuensis. Beshanzoides A-D (1-4, resp.) feature a cycloheptanone-containing isobenzofuran ring system hitherto unknown, which might be biosynthesized via two steps of aldol reactions starting from a common co-occurring isobenzofuran-type polyketide as the precursor. The new structures were elucidated by spectroscopic methods, electronic circular dichroism data, and single crystal X-ray diffraction analyses. Beshanzoide E (5) showed antimicrobial activity (MIC: 16 mu g mL(-1)) against Staphylococcus aureus, whereas (+/-)-strobide A (10) inhibited (MIC: 16 mu g mL(-1)) Candida albicans. Cyclopaldic acid (12) and 3-O-methyl-cyclopaldic acid (13) exhibited inhibitory effects against acetyl-CoA carboxylase 1 (ACC1) with IC50 values of 0.96 and 11.77 mu M, respectively. Compound 12 also inhibited (10 50 : 7.56 mu M) ATP-citrate Iyase (ACL).
WOS关键词ATP-CITRATE LYASE ; NATURAL-PRODUCTS ; BIODIVERSITY ; METABOLITES ; PHTHALIDES ; CHINA ; ACID
资助项目NSFC[21937002] ; NSFC[81773599] ; NSFC[21772025]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000729861500001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/299172]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
2.Taizhou Univ, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Ecol & Conservat, Taizhou 318000, Zhejiang, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Tongji Univ, Sch Med, Shanghai Skin Dis Hosp, Shanghai 200443, Peoples R China
5.Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Hao-Wei,Jiang, Chun-Xiao,Li, Jiyang,et al. Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis[J]. RSC ADVANCES,2021,11(63):39781-39789.
APA Chen, Hao-Wei.,Jiang, Chun-Xiao.,Li, Jiyang.,Li, Na.,Zang, Yi.,...&Hu, Jin-Feng.(2021).Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis.RSC ADVANCES,11(63),39781-39789.
MLA Chen, Hao-Wei,et al."Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis".RSC ADVANCES 11.63(2021):39781-39789.

入库方式： OAI收割

来源：上海药物研究所

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