Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.
文献类型：期刊论文
| 作者 | Wu Jie-Wei1,2,3; Tang Chun-Ping2,3 ; Yao Sheng2,3; Ke Chang-Qiang2,3; Ye Yang2,3,4
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2021-11-01 |
| 卷号 | 19期号:11页码:868-873 |
| 关键词 | Sesquiterpenoid dimer Carpesium abrotanoides L. Carabrane sesquiterpenoid Dicarabrol B Dicarabrol C 11R-hydroxycarabrol |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(21)60091-2 |
| 通讯作者 | Ye Yang(yye@simm.ac.cn) |
| 英文摘要 | Dicarabrols B and C (1 and 2), two new carabrane sesquiterpenoid dimers, along with one new carabrane sesquiterpenoid (3) were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data, and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. Dicarabrol B possesses a novel C-30 skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties, while dicarabrol C presents the unique linkage of a cyclopentane ring in the molecule. Dicarabrol C exhibited potent inhibitory effects on HL-60 cells with an IC50 value of 3.7 mu mol.L-1. |
| WOS关键词 | LACTONES ; CYTOTOXICITY ; DIMERS |
| 资助项目 | China National Key RD Program[2017YFE0195100] ; China National Key RD Program[2018YFC1707000] ; National Natural Science Foundation of China[21920102003] ; National Natural Science Foundation of China[81903485] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000723753700007 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299226]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ye Yang |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu Jie-Wei,Tang Chun-Ping,Yao Sheng,et al. Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2021,19(11):868-873. |
| APA | Wu Jie-Wei,Tang Chun-Ping,Yao Sheng,Ke Chang-Qiang,&Ye Yang.(2021).Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L..CHINESE JOURNAL OF NATURAL MEDICINES,19(11),868-873. |
| MLA | Wu Jie-Wei,et al."Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.".CHINESE JOURNAL OF NATURAL MEDICINES 19.11(2021):868-873. |
入库方式： OAI收割
来源：上海药物研究所
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