LncRNAs, the Molecules Involved in Communications With Colorectal Cancer Stem Cells
文献类型：期刊论文
| 作者 | Fan, Boyang1; Zhang, Qian2; Wang, Ning3; Wang, Guiyu1 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-01-27 |
| 卷号 | 12 |
| ISSN号 | 2234-943X |
| 关键词 | colorectal cancer cancer stem cell lncRNA chemoresistance metastasis signal pathway |
| DOI | 10.3389/fonc.2022.811374 |
| 通讯作者 | Wang, Ning(wangning@ems.hrbmu.edu.cn) ; Wang, Guiyu(guiywang@163.com) |
| 英文摘要 | Colorectal cancer stem cells (CRCSCs) can actively self-renew, as well as having multidirectional differentiation and tumor regeneration abilities. Because the high functional activities of CRCSCs are associated with low cure rates in patients with colorectal cancer, efforts have sought to determine the function and regulatory mechanisms of CRCSCs. To date, however, the potential regulatory mechanisms of CRCSCs remain incompletely understood. Many non-coding genes are involved in tumor invasion and spread through their regulation of CRCSCs, with long non-coding RNAs (lncRNAs) being important non-coding RNAs. LncRNAs may be involved in the colorectal cancer development and drug resistance through their regulation of CRCSCs. This review systematically evaluates the latest research on the ability of lncRNAs to regulate CRCSC signaling pathways and the involvement of these lncRNAs in colorectal cancer promotion and suppression. The regulatory network of lncRNAs in the CRCSC signaling pathway has been determined. Further analysis of the potential clinical applications of lncRNAs as novel clinical diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer may provide new ideas and protocols for the prevention and treatment of colorectal cancer. |
| WOS关键词 | LONG NONCODING RNA ; EPITHELIAL-MESENCHYMAL TRANSITION ; TUMOR-INITIATING CELLS ; DRIVES SELF-RENEWAL ; IN-VITRO EXPANSION ; COLON-CANCER ; UP-REGULATION ; PROMOTES ; ACTIVATION ; SOX2 |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000753704600001 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/127518]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Ning; Wang, Guiyu |
| 作者单位 | 1.Harbin Med Univ, Affiliated Hosp 2, Dept Colorectal Canc Surg, Harbin, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Colorectal Surg, Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Harbin Med Univ, Key Lab Cardiovasc Med Res, State Prov Key Labs Biomed Pharmaceut China, Coll Pharm,Dept Pharmacol,Minist Educ, Harbin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Boyang,Zhang, Qian,Wang, Ning,et al. LncRNAs, the Molecules Involved in Communications With Colorectal Cancer Stem Cells[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Fan, Boyang,Zhang, Qian,Wang, Ning,&Wang, Guiyu.(2022).LncRNAs, the Molecules Involved in Communications With Colorectal Cancer Stem Cells.FRONTIERS IN ONCOLOGY,12. |
| MLA | Fan, Boyang,et al."LncRNAs, the Molecules Involved in Communications With Colorectal Cancer Stem Cells".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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