Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications
文献类型：期刊论文
| 作者 | Feng, Chuanlin1,2; Yu, Biao2,3 ; Song, Chao2,3; Wang, Junjun2; Zhang, Lei2; Ji, Xinmiao2; Wang, Ying2,3; Fang, Yanwen4; Liao, Zhongcai4; Wei, Min4
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| 刊名 | CELLS
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 11 |
| 关键词 | static magnetic fields diabetic wound healing oxidative stress NRF2 physical therapy |
| DOI | 10.3390/cells11030443 |
| 通讯作者 | Zhang, Xin(xinzhang@hmfl.ac.cn) |
| 英文摘要 | Although some studies have shown that some static magnetic fields (SMFs) can promote wound healing in diabetic mice, it is not clear whether the other diabetes complications, such as liver disease and diabetic nephropathy, can also be alleviated. Here, we constructed two simple magnetic plates using neodymium permanent magnets to examine the comprehensive effects of moderate SMFs on genetically obese leptin receptor-deficient db/db diabetic mice. We found that although the blood glucose was not obviously reduced by these two SMF settings, both of the glycated serum protein (GSP) and malondialdehyde (MDA) levels were significantly decreased (Cohen's d = 2.57-3.04). Moreover, the wound healing, liver lipid accumulation, and renal defects were all significantly improved by SMF treatment (Cohen's d = 0.91-2.05). Wound tissue examination showed obvious nuclear factor erythroid 2-related factor 2 (NRF2) level decrease (Cohen's d = 2.49-5.40) and Ki-67 level increase (Cohen's d = 2.30-3.40), indicating decreased oxidative stress and increased cell proliferation. In vitro cellular studies with fibroblast NIH3T3 cells showed that SMFs could reduce high glucose-induced NRF2 nucleus translocation (Cohen's d = 0.87-1.15) and cellular reactive oxygen species (ROS) elevation (Cohen's d = 0.92), indicating decreased oxidative stress. Consequently, high glucose-induced impairments in cell vitality, proliferation, and migration were all improved by SMF treatment. Therefore, our results demonstrate that these simple SMF devices could effectively reduce oxidative stress in diabetic mice and may provide a cost-effective physical therapy strategy to alleviate multiple diabetic complications in the future. |
| WOS关键词 | KEAP1-NRF2 PATHWAY ; MECHANISMS ; INTENSITY ; DISEASE ; IMPACT ; DNA |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000754895200001 |
| 出版者 | MDPI |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/127584]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230039, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Grad Sch, Sci Isl Branch, Hefei 230026, Peoples R China 4.Heye Hlth Technol Co Ltd, Huzhou 313300, Peoples R China 5.Int Magnetobiol Frontier Res Ctr iMFRC, Sci Isl, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Chuanlin,Yu, Biao,Song, Chao,et al. Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications[J]. CELLS,2022,11. |
| APA | Feng, Chuanlin.,Yu, Biao.,Song, Chao.,Wang, Junjun.,Zhang, Lei.,...&Zhang, Xin.(2022).Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications.CELLS,11. |
| MLA | Feng, Chuanlin,et al."Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications".CELLS 11(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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