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Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses

文献类型：期刊论文

作者Wei, Xiaoxia1; Jiang, Xiangxiang1; Zhang, Xu1; Fan, Xikang1; Ji, Mengmeng1; Huang, Yanqian1; Xu, Jing2; Yin, Rong3; Wang, Yuzhuo1; Zhu, Meng1,3,4
刊名FRONTIERS IN ONCOLOGY
出版日期2022-02-14
卷号12
ISSN号2234-943X
关键词lung cancer neuroticism genetic risk prospective analysis Mendelian randomization study
DOI10.3389/fonc.2022.836159
通讯作者Hang, Dong(hangdong@njmu.edu.cn) ; Ma, Hongxia(hongxiama@njmu.edu.cn)
英文摘要BackgroundIt remains undetermined whether neuroticism affects the risk of lung cancer. Therefore, we performed complementary observational and Mendelian randomization (MR) analyses to investigate the association between neuroticism and lung cancer risk. MethodsWe included 364,451 UK Biobank participants free of cancer at baseline. Neuroticism was ascertained using the 12-item of Eysenck Personality Inventory Neuroticism Scale. Multivariable Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Two-sample MR analysis was carried out with summary genetic data from UK Biobank (374,323 individuals) and International Lung Cancer Consortium (29,266 lung cancer cases and 56,450 controls). Furthermore, we calculated a polygenic risk score of lung cancer, and examined the joint-effect and interaction between neuroticism and genetic susceptibility on lung cancer risk. ResultsDuring a median follow-up of 7.13 years, 1573 lung cancer cases were documented. After adjusting for smoking and other confounders, higher neuroticism was associated with an increased risk of lung cancer (HR (per 1 SD)=1.07, 95% CI: 1.02-1.12). Consistently, MR analysis suggested a causal effect of neuroticism on lung cancer risk (OR (IVW)=1.10, 95% CI: 1.03-1.17). Compared to individuals with low neuroticism and low PRS, those with both high neuroticism and high PRS had the greatest risk of lung cancer (HR=1.82, 95%CI: 1.51-2.20). Furthermore, there was a positive additive but no multiplicative interaction between neuroticism and genetic risk. ConclusionsOur findings suggest that neuroticism is associated with an elevated risk of incident lung cancer, which is strengthened by the genetic susceptibility to lung cancer. Further studies are necessary to elucidate underlying mechanisms.
WOS关键词PERSONALITY-TRAITS ; INSTRUMENTS ; METAANALYSIS ; DISORDERS ; STABILITY ; MORTALITY ; ANXIETY ; ROBUST ; MODEL
资助项目National Natural Science Foundation of China[81922061] ; National Natural Science Foundation of China[81803306] ; Natural Science Foundation of Jiangsu Province[BK20180675] ; CAMS Innovation Fund for Medical Sciences[2019RU038] ; National Science Foundation for Post-doctoral Scientists of China[2018M640466]
WOS研究方向Oncology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000761669100001
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; CAMS Innovation Fund for Medical Sciences ; National Science Foundation for Post-doctoral Scientists of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/127915]  
专题中国科学院合肥物质科学研究院
通讯作者Hang, Dong; Ma, Hongxia
作者单位1.Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China
2.Nanjing Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Nanjing, Peoples R China
3.Nanjing Med Univ, Jiangsu Key Lab Mol & Translat Canc Res, Dept Thorac Surg,Jiangsu Inst Canc Res, Jiangsu Canc Hosp,Affiliated Canc Hosp, Nanjing, Peoples R China
4.Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China
5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R China
6.Chinese Acad Sci, Inst Basic Med & Canc, Hangzhou, Peoples R China
7.Chinese Acad Med Sci, Res Units Cohort Study Cardiovasc Dis & Canc, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Xiaoxia,Jiang, Xiangxiang,Zhang, Xu,et al. Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses[J]. FRONTIERS IN ONCOLOGY,2022,12.
APA Wei, Xiaoxia.,Jiang, Xiangxiang.,Zhang, Xu.,Fan, Xikang.,Ji, Mengmeng.,...&Ma, Hongxia.(2022).Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses.FRONTIERS IN ONCOLOGY,12.
MLA Wei, Xiaoxia,et al."Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses".FRONTIERS IN ONCOLOGY 12(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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