This study calculated the Thorpe scale, thickness of turbulent layer, turbulent kinetic energy dissipation rate, and turbulent diffusion coefficient based on the Thorpe method using a set of near-space high-resolution radiosonde data in northwest China, and a case study was conducted to analyze the large-scale turbulent layer in the middle stratosphere. The results showed that the most turbulent layers exist near from the middle and upper troposphere to the tropopause region, accounting for 44.0% of the total turbulence, and the largest Thorpe scale and thickness of turbulent layer also appear in this altitude range. In addition, affected by the large-scale turbulence near the tropopause, the calculated turbulent energy dissipation rate and diffusion coefficient also have maximum values at this altitude, which are 0.003 m(2)s(-3) and 6.94 m(2)s(-1), respectively. By analyzing the meteorological elements, it is found that there is an obvious correlation between precipitation and large-scale turbulence in the stratosphere. When the precipitation occurs, the corresponding two sets of radiosondes detected larger-scale turbulence layers in the middle stratosphere.