In Vitro Anti-Inflammatory and Skin Moisturizing Properties of Pilea martini (Levl.) Hand.-Mazz. Extracts
文献类型：期刊论文
| 作者 | Choi, Jieun; Jung, Young Yun2; Ha, In Jin3; Baek, Seung Ho4; Zhang, Zhiyun5; Kim, Soo-Yong; Hong, Yejin; Kim, Sungyoon; Yeum, Hye Won; Jeon, Sae-Rom |
| 刊名 | NATURAL PRODUCT COMMUNICATIONS
 |
| 出版日期 | 2020 |
| 卷号 | 15期号:11 |
| ISSN号 | 1934-578X |
| 关键词 | Pilea martini NF-kappa B AP-1 MAPKs filaggrin SPT |
| DOI | 10.1177/1934578X20967866 |
| 文献子类 | Article |
| 英文摘要 | The in vitro anti-inflammatory and skin moisturizing activities of Pilea martini (Levl.) Hand.-Mazz. were investigated on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and human immortalized keratinocytes. Chromatographic analysis was performed to identify the chemical composition of the extracts. Pilea martini extracts significantly suppressed LPS-induced nitric oxide, prostaglandin E2, interleukin 6, and tumor necrosis factor alpha production in dose-dependent manners. In addition, the extracts inhibited LPS-induced inducible nitric oxide synthase and cyclooxygenase-2 proteins and their mRNA expression through causing a downregulation of nuclear factor-kappa B, activator protein 1, and mitogen-activated protein kinase signaling cascades. The extracts increased the production of hyaluronic acid levels and enhanced the expression levels of both filaggrin and serine palmitoyltransferase regulation. Liquid chromatography-mass spectroscopy analysis showed that the extracts contained 6 different compounds (malic acid, tryptophan, chlorogenic acid, caffeic acid, p-coumaric acid, and isoquercetin) that may contribute to their bioactivities. Taken together, Pilea martini extract showed remarkable promise as an anti-inflammatory and moisturizing agent. |
| 学科主题 | Chemistry, Medicinal ; Food Science & Technology |
| 电子版国际标准刊号 | 1555-9475 |
| 出版地 | THOUSAND OAKS |
| WOS研究方向 | Pharmacology & Pharmacy ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS INC |
| WOS记录号 | WOS:000593537600001 |
| 资助机构 | National Research Foundation of KoreaNational Research Foundation of Korea [NRF--2017M3A9E4057932] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/21511]  |
| 专题 | 系统与进化植物学国家重点实验室 |
| 作者单位 | 1.Kyung Hee Univ, Dept Acupuncture & Moxibust, Seoul, South Korea 2.Ky Ung Hee Univ, Grad Sch, Dept Clin Korean Med, Seoul, South Korea 3.Kyung Hee Univ, Dept Sci Korean Med, Seoul, South Korea 4.Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr K CTC, Seoul, South Korea 5.Dongguk Univ, Coll Korean Med, Goyang Si, South Korea 6.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China 7.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon, South Korea |
| 推荐引用方式 GB/T 7714 | Choi, Jieun,Jung, Young Yun,Ha, In Jin,et al. In Vitro Anti-Inflammatory and Skin Moisturizing Properties of Pilea martini (Levl.) Hand.-Mazz. Extracts[J]. NATURAL PRODUCT COMMUNICATIONS,2020,15(11). |
| APA | Choi, Jieun.,Jung, Young Yun.,Ha, In Jin.,Baek, Seung Ho.,Zhang, Zhiyun.,...&Nam, Dongwoo.(2020).In Vitro Anti-Inflammatory and Skin Moisturizing Properties of Pilea martini (Levl.) Hand.-Mazz. Extracts.NATURAL PRODUCT COMMUNICATIONS,15(11). |
| MLA | Choi, Jieun,et al."In Vitro Anti-Inflammatory and Skin Moisturizing Properties of Pilea martini (Levl.) Hand.-Mazz. Extracts".NATURAL PRODUCT COMMUNICATIONS 15.11(2020). |
入库方式： OAI收割
来源：植物研究所
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