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Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.

文献类型：期刊论文

作者Li, Lin1; Josef, Brinckmann A.; Liu, Bing3; Zheng, Sihao1; Huang, Linfang1; Chen, Shilin4
刊名FRONTIERS IN PLANT SCIENCE
出版日期2017
卷号8
关键词Artemisia annua artemisinin DNA barcoding ecotype ecotypic diversity
ISSN号1664-462X
DOI10.1016/j.biocon.2017.09.011
文献子类Article
英文摘要Artemisinin is the first-line drug for anti-malaria recommended by the World Health Organization (WHO). As the sole natural plant source of artemisinin, ecotypes of Artemisia annua L. vary widely in artemisinin content between nations, and China is the main producing area of A. annua. Here we present a three-dimensional evaluation on ecotypic diversity of A. annua from 12 main producing areas in China using highperformance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) method, DNA barcoding and ecological analyses. The results indicated that A. annua exhibited high ecotypic diversity. A. annua grown in the South of the Qinling Mountains-Huaihe River Line had a high artemisinin content, whereas the northern ones were low. Similar pattern was noted in the genetic diversity. The southern A. annua had high intraspecific variation in contrast to the northern A. annua. In terms of ecological analyses, humidity and sunshine time could be the major limiting ecological factors that affect the accumulation of artemisinin. This is the first reported threedimensional evaluation integrating chemical, molecular and ecological analyses of the ecotypic diversity of A. annua. The work will facilitate exploring the genetic basis of chemical variations and developing strategies for the breeding and cultivation of high quality A. annua.
学科主题Biodiversity & Conservation ; Environmental Sciences & Ecology
出版地LAUSANNE
WOS关键词PERFORMANCE LIQUID-CHROMATOGRAPHY ; DNA BARCODE ; GENETIC-CHARACTERIZATION ; ADAPTATION ; BIOMASS ; PROFILE ; GROWTH
语种英语
WOS记录号WOS:000414883000018
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473315] ; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-12M-3-015]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/22273]  
专题植物研究所_系统与进化植物学研究中心_系统与进化植物学研究中心_学位论文
作者单位1.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China
2.Peking Union Med Coll, Beijing, Peoples R China
3.Josef, Brinckmann A.] Sustainabil Dept, Tradit Med, Sebastopol, CA USA
4.Chinese Acad Sci, Inst Bot, Beijing, Peoples R China
5.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lin,Josef, Brinckmann A.,Liu, Bing,et al. Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.[J]. FRONTIERS IN PLANT SCIENCE,2017,8.
APA Li, Lin,Josef, Brinckmann A.,Liu, Bing,Zheng, Sihao,Huang, Linfang,&Chen, Shilin.(2017).Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L..FRONTIERS IN PLANT SCIENCE,8.
MLA Li, Lin,et al."Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.".FRONTIERS IN PLANT SCIENCE 8(2017).

入库方式： OAI收割

来源：植物研究所

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