Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering
文献类型：期刊论文
| 作者 | Xing, Lijing; Liu, Yan4; Xu, Shujuan5; Xiao, Jun3; Wang, Bo5; Deng, Hanwen5; Lu, Zhuang; Xu, Yunyuan; Chong, Kang2,5 |
| 刊名 | EMBO JOURNAL
 |
| 出版日期 | 2018 |
| 卷号 | 37期号:19 |
| 关键词 | ATX1 HKMT activity O-GlcNAcylation SEC |
| ISSN号 | 0261-4189 |
| DOI | 10.15252/embj.201798115 |
| 文献子类 | Article |
| 英文摘要 | Post-translational modification of proteins by O-linked -N-acetylglucosamine (O-GlcNAc) is catalyzed by O-GlcNAc transferases (OGTs). O-GlcNAc modification of proteins regulates multiple important biological processes in metazoans. However, whether protein O-GlcNAcylation is involved in epigenetic processes during plant development is largely unknown. Here, we show that loss of function of SECRET AGENT (SEC), an OGT in Arabidopsis, leads to an early flowering phenotype. This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering. SEC activates ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1), a histone lysine methyltransferase (HKMT), through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histone modification at FLC locus. SEC transfers an O-GlcNAc group on Ser947 of ATX1,which resides in the SET domain, thereby activating ATX1. Taken together, these results uncover a novel post-translational O-GlcNAc modification-mediated mechanism for regulation of HKMT activity and establish the function of O-GlcNAc signaling in epigenetic processes in plants. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 出版地 | HOBOKEN |
| 电子版国际标准刊号 | 1460-2075 |
| WOS关键词 | BETA-N-ACETYLGLUCOSAMINE ; TRITHORAX GROUP PROTEINS ; POLYCOMB-GROUP PROTEINS ; GROWTH REPRESSOR DELLA ; LOCUS-C ; PLANT DEVELOPMENT ; H3K4 METHYLATION ; DOMAIN PROTEIN ; COMPLEX 2 ; GLCNACYLATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000446029400003 |
| 出版者 | WILEY |
| 资助机构 | Basic Science Center Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31788103] ; National Key Research and Development Program of China [2016YFD0101004] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/20393]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Natl Ctr Plant Gene Res, Beijing, Peoples R China 2.Chinese Acad Sci, State Key Lab Plant Cell & Chromosome Engn, Inst Genet & Dev Biol, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Key Lab Plant Mol Physiol, Inst Bot, Beijing, Peoples R China 5.Northeast Agr Univ, Coll Hort, Harbin, Heilongjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Lijing,Liu, Yan,Xu, Shujuan,et al. Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering[J]. EMBO JOURNAL,2018,37(19). |
| APA | Xing, Lijing.,Liu, Yan.,Xu, Shujuan.,Xiao, Jun.,Wang, Bo.,...&Chong, Kang.(2018).Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering.EMBO JOURNAL,37(19). |
| MLA | Xing, Lijing,et al."Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering".EMBO JOURNAL 37.19(2018). |
入库方式： OAI收割
来源：植物研究所
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