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Epigenetic switch from repressive to permissive chromatin in response to cold stress

文献类型：期刊论文

作者Park, Junghoon; Lim, Chae Jin; Shen, Mingzhe; Park, Hee Jin7; Cha, Joon-Yung; Iniesto, Elisa6; Rubio, Vicente6; Mengiste, Tesfaye5; Zhu, Jian-Kang; Bressan, Ray A.
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2018
卷号115期号:23页码:E5400-E5409
关键词histone acetylation derepression cold stress response CUL4-based E3 ligase HOS15
ISSN号0027-8424
DOI10.1073/pnas.1721241115
文献子类Article
英文摘要Switching from repressed to active status in chromatin regulation is part of the critical responses that plants deploy to survive in an ever-changing environment. We previously reported that HOS15, a WD40-repeat protein, is involved in histone deacetylation and cold tolerance in Arabidopsis. However, it remained unknown how HOS15 regulates cold responsive genes to affect cold tolerance. Here, we show that HOS15 interacts with histone deacetylase 2C (HD2C) and both proteins together associate with the promoters of cold-responsive COR genes, COR15A and COR47. Cold induced HD2C degradation is mediated by the CULLIN4 (CUL4)-based E3 ubiquitin ligase complex in which HOS15 acts as a substrate receptor. Interference with the association of HD2C and the COR gene promoters by HOS15 correlates with increased acetylation levels of histone H3. HOS15 also interacts with CBF transcription factors to modulate cold-induced binding to the COR gene promoters. Our results here demonstrate that cold induces HOS15-mediated chromatin modifications by degrading HD2C. This switches the chromatin structure status and facilitates recruitment of CBFs to the COR gene promoters. This is an apparent requirement to acquire cold tolerance.
学科主题Multidisciplinary Sciences
出版地WASHINGTON
WOS关键词PROTEIN-PROTEIN INTERACTIONS ; ARABIDOPSIS DWD PROTEIN ; TRANSCRIPTION FACTORS ; FREEZING TOLERANCE ; UBIQUITIN LIGASE ; HISTONE DEACETYLASE ; GENE ; ACCLIMATION ; EXPRESSION ; REGULATOR
语种英语
WOS记录号WOS:000434114900020
出版者NATL ACAD SCIENCES
资助机构National Research Foundation of KoreaNational Research Foundation of Korea ; Korean GovernmentKorean Government [MSIP 2016R1A2A1A05004931] ; Korean Government (Global Research Laboratory)Korean Government [2017K1A1A2013146] ; Next-Generation BioGreen 21 Program SSAC, Rural Development Administration, Republic of Korea [PJ01318201, PJ01318205, PJ01327301] ; Agencia Estatal de Investigacion of Ministerio de Economia, Industria y Competitividad ; European Regional Development FundEuropean Commission [BIO2016-80551-R]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/20400]  
专题中科院植物分子生理学重点实验室
作者单位1.Pardo, Jose M.] CSIC, Inst Plant Biochem & Photosynth, Seville 41092, Spain
2.Sogang Univ, Dept Life Sci, Seoul 04107, South Korea
3.Zhu, Jian-Kang; Bressan, Ray A.] Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47907 USA
4.Purdue Univ, Dept Bot & Plant Pathol, W Lafayette, IN 47907 USA
5.CSIC, Ctr Nacl Biotecnol, Plant Mol Genet Dept, Campus Univ Autonoma Madrid, E-28049 Madrid, Spain
6.Konkuk Univ, Inst Glocal Dis Control, Seoul 05029, South Korea
7.Gyeongsang Natl Univ, Plant Mol Biol & Biotechnol Res Ctr, Inst Agr & Life Sci, Div Appl Life Sci,BK21 Plus Program, Jinju 52828, South Korea
8.Konkuk Univ, Dept Biomed Sci & Engn, Seoul 05029, South Korea
9.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China
推荐引用方式
GB/T 7714		 Park, Junghoon,Lim, Chae Jin,Shen, Mingzhe,et al. Epigenetic switch from repressive to permissive chromatin in response to cold stress[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(23):E5400-E5409.
APA Park, Junghoon.,Lim, Chae Jin.,Shen, Mingzhe.,Park, Hee Jin.,Cha, Joon-Yung.,...&Yun, Dae-Jin.(2018).Epigenetic switch from repressive to permissive chromatin in response to cold stress.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(23),E5400-E5409.
MLA Park, Junghoon,et al."Epigenetic switch from repressive to permissive chromatin in response to cold stress".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.23(2018):E5400-E5409.

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来源：植物研究所

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