Global analysis of H3K4me3/H3K27me3 in Brachypodium distachyon reveals VRN3 as critical epigenetic regulation point in vernalization and provides insights into epigenetic memory
文献类型：期刊论文
| 作者 | Huan, Qing2; Mao, Zhiwei; Chong, Kang; Zhang, Jingyu |
| 刊名 | NEW PHYTOLOGIST
 |
| 出版日期 | 2018 |
| 卷号 | 219期号:4页码:1373-1387 |
| 关键词 | Brachypodium distachyon chromatin immunoprecipitation-sequencing (ChIP-Seq) epigenetic regulation flowering control histone modification vernalization |
| ISSN号 | 0028-646X |
| DOI | 10.1111/nph.15288 |
| 文献子类 | Article |
| 英文摘要 | Vernalization, the requirement of plants for long-term exposure to low environmental temperature for flowering, is an epigenetic phenomenon. Histone modification regulation has been revealed in vernalization, but is limited to key genes. Now, we know that VRN1 is epigenetically critical for monocots. Genome-wide analysis is still unavailable, however. We performed chromatin immunoprecipitation-sequencing for H3K4me3/H3K27me3 in Brachypodium distachyon to obtain a global view of histone modifications in vernalization on a genome-wide scale and for different pathways/genes. Our data showed that H3K4me3 and H3K27me3 play distinct roles in vernalization. Unlike H3K4me3, H3K27me3 exhibited regional regulation, showed main regulation targets in vernalization and contributed to epigenetic memory. For genes in four flowering regulation pathways, only FT2 (functional ortholog of VRN3 in B.distachyon) and VRN1 showed coordinated changes in H3K4me3/H3K27me3. The epigenetic response at VRN3 was weaker under short-day than under long-day conditions. VRN3 was revealed as an epigenetic regulation point integrating vernalization and day length signals. We globally identified genes maintaining vernalization-induced epigenetic changes. Most of these genes showed dose-dependent vernalization responses, revealing a quantitative recording system' for vernalization. Our studies shed light on the epigenetic role of VRN3 and H3K4me3/H3K27me3 in vernalization and reveal genes underlying epigenetic memory, laying the foundation for further study. |
| 学科主题 | Plant Sciences |
| 出版地 | HOBOKEN |
| 电子版国际标准刊号 | 1469-8137 |
| WOS关键词 | HISTONE METHYLATION ; FLOWERING-TIME ; BARLEY ; GENES ; WHEAT ; H3K27ME3 ; WINTER ; COLD ; ARABIDOPSIS ; PHOTOPERIOD |
| 语种 | 英语 |
| WOS记录号 | WOS:000440847600024 |
| 出版者 | WILEY |
| 资助机构 | National Key Research and Development Program of China [2016YFD0100604] ; CAS-CSIRO Project of the Chinese Academy of Sciences ; Key External Cooperation Program of the Chinese Academy of Sciences [GJHZ1728] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/20677]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huan, Qing,Mao, Zhiwei,Chong, Kang,et al. Global analysis of H3K4me3/H3K27me3 in Brachypodium distachyon reveals VRN3 as critical epigenetic regulation point in vernalization and provides insights into epigenetic memory[J]. NEW PHYTOLOGIST,2018,219(4):1373-1387. |
| APA | Huan, Qing,Mao, Zhiwei,Chong, Kang,&Zhang, Jingyu.(2018).Global analysis of H3K4me3/H3K27me3 in Brachypodium distachyon reveals VRN3 as critical epigenetic regulation point in vernalization and provides insights into epigenetic memory.NEW PHYTOLOGIST,219(4),1373-1387. |
| MLA | Huan, Qing,et al."Global analysis of H3K4me3/H3K27me3 in Brachypodium distachyon reveals VRN3 as critical epigenetic regulation point in vernalization and provides insights into epigenetic memory".NEW PHYTOLOGIST 219.4(2018):1373-1387. |
入库方式： OAI收割
来源：植物研究所
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