Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides
文献类型：期刊论文
| 作者 | Qian, Dandan; Qiu, Bin1,4; Zhou, Nan; Takaiwa, Fumio2; Yong, Weidong1,4; Qu, Le Qing |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 68期号:27页码:7162-7168 |
| ISSN号 | 0021-8561 |
| 关键词 | antihypertensive peptide transgenic rice hypertension food-derived bioactive peptide spontaneously hypertensive rats systolic blood pressure |
| DOI | 10.1021/acs.jafc.0c01958 |
| 文献子类 | Article |
| 英文摘要 | Peptides derived from food protein have the potential to become antihypertensive agents with relatively few negative side effects. Herein, multiple antihypertensive peptides, extracted from the transgenic rice seed, were administered intragastrically into spontaneously hypertensive rats (SHRs) with different dosages, resulting in a significant decrease in the systolic blood pressure (SBP). Furthermore, for a period of 5 weeks, daily intragastric administration of the transgenic rice flour also significantly reduced the SBP of SHRs but not the Wistar Kyoto normotensive rats (WNRs), most importantly, which did not affect the growth, development, or serum chemistry of SHRs or WNRs and did not cause any pathological changes. Our work provides an alternative source of natural antihypertensive agents. |
| 学科主题 | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| 电子版国际标准刊号 | 1520-5118 |
| 出版地 | WASHINGTON |
| WOS关键词 | I-CONVERTING-ENZYME ; INHIBITORY PEPTIDES ; BLOOD-PRESSURE ; EXPRESSION ; PROTEIN ; DESIGN |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000550642300010 |
| 资助机构 | National Program of Transgenic Variety Development of China [2016ZX08001-006] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/21669]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China 2.Peking Union Med Coll, Beijing 100021, Peoples R China 3.Natl Agr & Food Res Org, Div Biotechnol, Plant Mol Farming Unit, Inst Agrobiol Sci, Tsukuba, Ibaraki 3058602, Japan 4.Chinese Acad Sci, Innovat Acad Seed Design, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Dandan,Qiu, Bin,Zhou, Nan,et al. Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(27):7162-7168. |
| APA | Qian, Dandan,Qiu, Bin,Zhou, Nan,Takaiwa, Fumio,Yong, Weidong,&Qu, Le Qing.(2020).Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(27),7162-7168. |
| MLA | Qian, Dandan,et al."Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.27(2020):7162-7168. |
入库方式： OAI收割
来源：植物研究所
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