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Crystal structure of Arabidopsis thaliana cytidine deaminase

文献类型：期刊论文

作者Wang, Jia3; Guo, Qi3; Liu, Lin1; Wang, Xiao1
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2020
卷号529期号:3页码:659-665
关键词Pyrimidine metabolism RNA editing Crystallography Catalytic mechanism
ISSN号0006-291X
DOI10.1016/j.bbrc.2020.06.084
文献子类Article
英文摘要Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants. CDA serves as a prototype of the cytidine deaminase superfamily that contains a number of RNA editing enzymes. Arabidopsis thaliana has only one functional CDA, AtCDA1. We solved the crystal structures of AtCDA1, which is a dimeric zinccontaining enzyme and each protomer consists of an N-terminal zinc-binding catalytic domain and a C-terminal non-catalytic domain. Both domains adopt a typical alpha/beta/alpha sandwich fold. In vitro biochemical assays showed that the ribose moiety of cytidine is required for ligand binding, and structural analyses revealed a conserved catalytic mechanism is adopted by AtCDA1. (C) 2020 Elsevier Inc. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Biophysics
出版地SAN DIEGO
电子版国际标准刊号1090-2104
WOS关键词FAMILY PROTEINS ; CHLOROPHYLL-A ; PYRIMIDINE ; ENZYME ; MODEL
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000555780500022
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构National Key R&D Program of China [2017YFA0503703] ; China Postdoctoral Science FundChina Postdoctoral Science Foundation [2018M632517] ; Provincial Natural Science Foundation of Anhui [1908085QC129]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/21644]  
专题中科院光生物学重点实验室
作者单位1.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
2.Anhui Univ, Sch Life Sci, Duxing North Bldg,Rm B305,111 Jiulong Rd, Hefei 230601, Anhui, Peoples R China
3.Chinese Acad Sci, Inst Bot, CAS Key Lab Photobiol, Beijing 100093, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jia,Guo, Qi,Liu, Lin,et al. Crystal structure of Arabidopsis thaliana cytidine deaminase[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,529(3):659-665.
APA Wang, Jia,Guo, Qi,Liu, Lin,&Wang, Xiao.(2020).Crystal structure of Arabidopsis thaliana cytidine deaminase.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,529(3),659-665.
MLA Wang, Jia,et al."Crystal structure of Arabidopsis thaliana cytidine deaminase".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 529.3(2020):659-665.

入库方式： OAI收割

来源：植物研究所

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