In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free
文献类型：期刊论文
| 作者 | Wang, Zhanzhong; Liu, Xiaoxue; Li, Qing; Qiu, Shuang; Wang, Xueping; Byambasuren, Khorolgarav; Liu, Zhengan2 ; Dang, Leping; Shu, Qingyan2
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2020 |
| 卷号 | 68期号:33页码:8996-9003 |
| 关键词 | fluorescent microemulsion antidigestion remarkable fluorescence intensity release property label-free delivery carrier |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.0c00341 |
| 文献子类 | Article |
| 英文摘要 | In this work, a microemulsion emitting fluorescence was fabricated as a potential oral delivery system for bioactive compounds. In simulated oral administration, the microemulsion was characterized for its microstructure by 'hydrogen-nuclear magnetic resonance (H-1-NMR). Results showed that microemulsions not only have good resistance to oral and gastric phases, but also lay a solid foundation for the release of bioactive compounds in the intestine. Fluorescence stability tests showed that microemulsions exhibit a remarkable fluorescence intensity in the digestive environment, indicating feasibility as a label-free delivery carrier. Moreover, in vitro release tests of bioactive compounds confirmed that an alpha-linolenic acid (ALA)-loaded microemulsion mainly released in the intestine, thereby achieving the aim of controlling the release of bioactive compounds. These results suggest that the synthesized fluorescent microemulsion, combining the favorable features of nontoxicity, antidigestive stability, remarkable fluorescence intensity, and controllable release, can be regarded as a promising label-free delivery carrier for oral administration. |
| 学科主题 | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| 出版地 | WASHINGTON |
| 电子版国际标准刊号 | 1520-5118 |
| WOS关键词 | LIPID DIGESTION ; EMULSIONS ; BIOACCESSIBILITY ; BIOAVAILABILITY ; NANOPARTICLES ; NANOEMULSIONS ; ENCAPSULATION ; BIOPOLYMER ; STABILITY ; CAPACITY |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000563071500025 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA23080601] ; Key Laboratory of Plant Resources, Institute of Botany, the Chinese Academy of Sciences [KLPR2019-02, 2019GKF-0238] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21978206] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/21613]  |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing Bot Garden, Beijing 100093, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhanzhong,Liu, Xiaoxue,Li, Qing,et al. In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(33):8996-9003. |
| APA | Wang, Zhanzhong.,Liu, Xiaoxue.,Li, Qing.,Qiu, Shuang.,Wang, Xueping.,...&Shu, Qingyan.(2020).In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(33),8996-9003. |
| MLA | Wang, Zhanzhong,et al."In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.33(2020):8996-9003. |
入库方式： OAI收割
来源：植物研究所
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