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Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics

文献类型：期刊论文

作者Li, Qing; Liu, Xiaoxue; Byambasuren, Khorolgarav; Wang, Xueping; Qiu, Shuang; Gao, Yujie; Dang, Leping; Liu, Zhengan1; Shu, Qingyan1; Wang, Zhanzhong
刊名JOURNAL OF MOLECULAR LIQUIDS
出版日期2020
卷号303
关键词W1/O/W-2 microemulsion Multi-scale molecules Properties Antioxidant capacity Release kinetics
ISSN号0167-7322
DOI10.1016/j.molliq.2020.112675
文献子类Article
英文摘要The effects of multi-scale molecules on physical properties, antioxidant capacity and in vitro release kinetics in the alpha-linolenic acid-loaded water-in-oil-in-water (W-1/O/W-2) microemulsion were revealed in this work. The glucose and carboxymethyl cellulose sodium (CMC) solutions were selected as the internal aqueous phase (W-1) of the microemulsion, respectively, while the multi-scale molecules, such as sodium chloride (NaCl), glycine (Gly), glucose (Glu), CMC, bovine serum albumin (BSA) and sodium caseinate (SC), were added in the external aqueous phase (W-2) to balance the osmotic pressure and meanwhile their effects on the fluorescence property, antioxidant capacity and release kinetics were probed. Among these, the CMCw1-NaClw2 and Glu(w1)-CMCw2 microemulsion within the appropriate concentration range could dramatically increase the storage stability and antioxidant capacity by inhibiting the aggregation of droplets or Ostwald ripening, while the addition of Gly and SC had the negative effect on the stability of microemulsion. Finally, the release kinetic dates were fitted and the Koismeyer-Peppas equation was considered as the most suitable to explain the ALA release kinetics that were controlled by diffusion and erosion in the simulated gastric fluid (SGF, pH = 2.0) and simulated intestinal fluid (SIF, pH = 6.8). The application of release kinetic models in nutrient nano-delivery systems could facilitate the investigation on the release mechanism of nutritional components. (C) 2020 Published by Elsevier B.V.
学科主题Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
出版地AMSTERDAM
电子版国际标准刊号1873-3166
WOS关键词MULTIPLE W/O/W EMULSIONS ; STABILITY ; DELIVERY ; EMULSIFICATION ; ADDITIVES ; PROFILES ; BEHAVIOR ; SYSTEMS
WOS研究方向Chemistry ; Physics
语种英语
WOS记录号WOS:000533612700078
出版者ELSEVIER
资助机构Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA23080601] ; Tianjin Municipal Natural Science FoundationNatural Science Foundation of Tianjin [17JCYBJC20400]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/21760]  
专题中科院北方资源植物重点实验室
作者单位1.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
2.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing Bot Garden, Beijing 100093, Peoples R China
推荐引用方式
GB/T 7714		 Li, Qing,Liu, Xiaoxue,Byambasuren, Khorolgarav,et al. Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics[J]. JOURNAL OF MOLECULAR LIQUIDS,2020,303.
APA Li, Qing.,Liu, Xiaoxue.,Byambasuren, Khorolgarav.,Wang, Xueping.,Qiu, Shuang.,...&Wang, Zhanzhong.(2020).Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics.JOURNAL OF MOLECULAR LIQUIDS,303.
MLA Li, Qing,et al."Revealing the effects of multi-scale molecules on alpha-linolenic acid-loaded W-1/O/W-2 microemulsion: A combined study from physical properties, antioxidant capacity and in vitro release kinetics".JOURNAL OF MOLECULAR LIQUIDS 303(2020).

入库方式： OAI收割

来源：植物研究所

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