Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells
文献类型：期刊论文
| 作者 | Wang, Xiao-Feng; Li, Heng3; Jiang, Kun; Wang, Qi-Qi; Zheng, Yan-Hai; Tang, Wei3; Tan, Chang-Heng |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018 |
| 卷号 | 130页码:61-65 |
| 关键词 | Perilla frutescens Lamiaceae Monoterpenoid Anti-inflammation RAW264.7 cell |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2018.08.006 |
| 文献子类 | Article |
| 英文摘要 | Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. In present study, the low-polarity constituents of the aerial parts of P. frutescens were investigated and their anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were assayed. Three new furanoid monoterpenoids, named as frutescenones A - C (1-3), together with thirteen known compounds (4-16) were isolated and identified on the basis of extensive spectroscopic analysis and a single-crystal X-ray diffraction study. Among these components, 1 is an unusual monoterpenoid with 2,3'-bifuran skeleton, and 3 is a rare perillaketone-adenine hybrid heterodimer, while the revised NMR arrangements of 4 were reported at the first time. Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 出版地 | AMSTERDAM |
| 电子版国际标准刊号 | 1873-6971 |
| WOS关键词 | INHIBITION |
| 语种 | 英语 |
| WOS记录号 | WOS:000449129500010 |
| 出版者 | ELSEVIER |
| 资助机构 | Personalized Medicines - Molecular Signature -Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences, China [XDA12040315] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/20484]  |
| 专题 | 其他人员 |
| 作者单位 | 1.Chinese Acad Sci, Inst Bot, R&D Ctr Plant Factory, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiao-Feng,Li, Heng,Jiang, Kun,et al. Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells[J]. FITOTERAPIA,2018,130:61-65. |
| APA | Wang, Xiao-Feng.,Li, Heng.,Jiang, Kun.,Wang, Qi-Qi.,Zheng, Yan-Hai.,...&Tan, Chang-Heng.(2018).Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells.FITOTERAPIA,130,61-65. |
| MLA | Wang, Xiao-Feng,et al."Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells".FITOTERAPIA 130(2018):61-65. |
入库方式： OAI收割
来源：植物研究所
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