Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery
文献类型:期刊论文
作者 | He, Pengbo1,2,3,4![]() ![]() |
刊名 | FRONTIERS IN ONCOLOGY
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出版日期 | 2022-02-11 |
卷号 | 12页码:10 |
关键词 | scanned carbon-ion therapy moving target synchrotron flattop operation motion mitigation 4D dose calculation |
ISSN号 | 2234-943X |
DOI | 10.3389/fonc.2022.806742 |
通讯作者 | Li, Qiang(liqiang@impcas.ac.cn) |
英文摘要 | PurposeThe characteristic of pulsed beam delivery for synchrotron-based carbon-ion radiotherapy has led to the emergence of many scanning scenarios in order to improve the treatment efficiency and accuracy of moving target volume. Here, we aim to evaluate a novel breathing guidance motion mitigation performance under different synchrotron flattop operation modes in carbon-ion radiotherapy. MethodsWith the use of twelve 4DCT datasets of lung cancer patients who had been treated with respiratory-gated carbon-ion pencil beam therapy, range-adapted internal target volume (raITV) plans were optimized. Under the fixed flattop with single-energy and extended flattop with multi-energy synchrotron operation modes, the 4D treatments with breathing guidance and free breathing-based gated phase-controlled rescanning (PCR) beam delivery were simulated. Dose metrics (D95 and D5-D95 in clinical target volume (CTV)) and treatment time of the resulting 4D plans were compared. ResultsThe two synchrotron operation modes provided different scanning dynamics. For the free breathing-based PCR method delivered in the extended flattop operation mode, the averaged CTV-D95 values were 90.4% +/- 3.7%, 95.4% +/- 1.7%, 96.9% +/- 1.5%, 97.2% +/- 1.5%, and 97.3% +/- 1.5% for the 1-scanning, 2-PCR, 4-PCR, 6-PCR, and 8-PCR, respectively. For the breathing guidance-based PCR method delivered in the extended flattop mode, these values were 89.1% +/- 4.0%, 97.0% +/- 1.4%, 98.2% +/- 0.7%, 98.6% +/- 0.7%, and 98.9% +/- 0.7%, respectively. However, CTV-D95 significantly increased to 98.5% +/- 1.0% even with just 1-scanning breathing guidance-based fixed flattop operation mode (p < 0.01). Moreover, there was no significant difference in treatment time among the three technical combinations (p > 0.15). ConclusionsThe combination of the breathing guidance and PCR methods should be an alternative way for motion mitigation for the fixed flattop synchrotron operation mode. The target dose coverage and homogeneity could be further improved by the combination of the breathing guidance and PCR methods than the traditional PCR-only technology for the extended flattop synchrotron operation mode. |
WOS关键词 | RESPIRATORY-GATED DELIVERY ; MOVING TARGET IRRADIATION ; MOTION MITIGATION ; SYSTEM ; THERAPY ; OPTIMIZATION |
资助项目 | Youth Innovation Promotion Association, Chinese Academy of Sciences, China[2019405] ; National Natural Science Foundation of China[11705247] ; National Natural Science Foundation of China[11875299] ; National Key Research and Development Program of China[2018YFC0115702] |
WOS研究方向 | Oncology |
语种 | 英语 |
WOS记录号 | WOS:000761425500001 |
出版者 | FRONTIERS MEDIA SA |
资助机构 | Youth Innovation Promotion Association, Chinese Academy of Sciences, China ; National Natural Science Foundation of China ; National Key Research and Development Program of China |
源URL | [http://119.78.100.186/handle/113462/142020] ![]() |
专题 | 中国科学院近代物理研究所 |
通讯作者 | Li, Qiang |
作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | He, Pengbo,Li, Qiang. Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery[J]. FRONTIERS IN ONCOLOGY,2022,12:10. |
APA | He, Pengbo,&Li, Qiang.(2022).Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery.FRONTIERS IN ONCOLOGY,12,10. |
MLA | He, Pengbo,et al."Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery".FRONTIERS IN ONCOLOGY 12(2022):10. |
入库方式: OAI收割
来源:近代物理研究所
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