中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery

文献类型:期刊论文

作者He, Pengbo1,2,3,4; Li, Qiang1,2,3,4
刊名FRONTIERS IN ONCOLOGY
出版日期2022-02-11
卷号12页码:10
关键词scanned carbon-ion therapy moving target synchrotron flattop operation motion mitigation 4D dose calculation
ISSN号2234-943X
DOI10.3389/fonc.2022.806742
通讯作者Li, Qiang(liqiang@impcas.ac.cn)
英文摘要PurposeThe characteristic of pulsed beam delivery for synchrotron-based carbon-ion radiotherapy has led to the emergence of many scanning scenarios in order to improve the treatment efficiency and accuracy of moving target volume. Here, we aim to evaluate a novel breathing guidance motion mitigation performance under different synchrotron flattop operation modes in carbon-ion radiotherapy. MethodsWith the use of twelve 4DCT datasets of lung cancer patients who had been treated with respiratory-gated carbon-ion pencil beam therapy, range-adapted internal target volume (raITV) plans were optimized. Under the fixed flattop with single-energy and extended flattop with multi-energy synchrotron operation modes, the 4D treatments with breathing guidance and free breathing-based gated phase-controlled rescanning (PCR) beam delivery were simulated. Dose metrics (D95 and D5-D95 in clinical target volume (CTV)) and treatment time of the resulting 4D plans were compared. ResultsThe two synchrotron operation modes provided different scanning dynamics. For the free breathing-based PCR method delivered in the extended flattop operation mode, the averaged CTV-D95 values were 90.4% +/- 3.7%, 95.4% +/- 1.7%, 96.9% +/- 1.5%, 97.2% +/- 1.5%, and 97.3% +/- 1.5% for the 1-scanning, 2-PCR, 4-PCR, 6-PCR, and 8-PCR, respectively. For the breathing guidance-based PCR method delivered in the extended flattop mode, these values were 89.1% +/- 4.0%, 97.0% +/- 1.4%, 98.2% +/- 0.7%, 98.6% +/- 0.7%, and 98.9% +/- 0.7%, respectively. However, CTV-D95 significantly increased to 98.5% +/- 1.0% even with just 1-scanning breathing guidance-based fixed flattop operation mode (p < 0.01). Moreover, there was no significant difference in treatment time among the three technical combinations (p > 0.15). ConclusionsThe combination of the breathing guidance and PCR methods should be an alternative way for motion mitigation for the fixed flattop synchrotron operation mode. The target dose coverage and homogeneity could be further improved by the combination of the breathing guidance and PCR methods than the traditional PCR-only technology for the extended flattop synchrotron operation mode.
WOS关键词RESPIRATORY-GATED DELIVERY ; MOVING TARGET IRRADIATION ; MOTION MITIGATION ; SYSTEM ; THERAPY ; OPTIMIZATION
资助项目Youth Innovation Promotion Association, Chinese Academy of Sciences, China[2019405] ; National Natural Science Foundation of China[11705247] ; National Natural Science Foundation of China[11875299] ; National Key Research and Development Program of China[2018YFC0115702]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000761425500001
出版者FRONTIERS MEDIA SA
资助机构Youth Innovation Promotion Association, Chinese Academy of Sciences, China ; National Natural Science Foundation of China ; National Key Research and Development Program of China
源URL[http://119.78.100.186/handle/113462/142020]  
专题中国科学院近代物理研究所
通讯作者Li, Qiang
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
He, Pengbo,Li, Qiang. Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery[J]. FRONTIERS IN ONCOLOGY,2022,12:10.
APA He, Pengbo,&Li, Qiang.(2022).Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery.FRONTIERS IN ONCOLOGY,12,10.
MLA He, Pengbo,et al."Impact of Different Synchrotron Flattop Operation Modes on 4D Dosimetric Uncertainties for Scanned Carbon-Ion Beam Delivery".FRONTIERS IN ONCOLOGY 12(2022):10.

入库方式: OAI收割

来源:近代物理研究所

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