Duality of Interactions Between TGF-beta and TNF-alpha During Tumor Formation
文献类型：期刊论文
| 作者 | Liu, Zhi-wei1; Zhang, Yi-ming1; Zhang, Li-ying1,2; Zhou, Ting1; Li, Yang-yang1; Zhou, Gu-cheng1; Miao, Zhi-ming1; Shang, Ming1; He, Jin-peng3,4 ; Ding, Nan-3,4
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| 刊名 | FRONTIERS IN IMMUNOLOGY
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| 出版日期 | 2022-01-05 |
| 卷号 | 12页码:14 |
| 关键词 | TGF-beta TNF-alpha proliferation apoptosis inflammation genomic instability epithelial-mesenchymal transition |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2021.810286 |
| 通讯作者 | Liu, Yong-qi(liuyongqi73@163.com) |
| 英文摘要 | The tumor microenvironment is essential for the formation and development of tumors. Cytokines in the microenvironment may affect the growth, metastasis and prognosis of tumors, and play different roles in different stages of tumors, of which transforming growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha) are critical. The two have synergistic and antagonistic effect on tumor regulation. The inhibition of TGF-beta can promote the formation rate of tumor, while TGF-beta can promote the malignancy of tumor. TNF-alpha was initially determined to be a natural immune serum mediator that can induce tumor hemorrhagic necrosis, it has a wide range of biological activities and can be used clinically as a target to immune diseases as well as tumors. However, there are few reports on the interaction between the two in the tumor microenvironment. This paper combs the biological effect of the two in different aspects of different tumors. We summarized the changes and clinical medication rules of the two in different tissue cells, hoping to provide a new idea for the clinical application of the two cytokines. |
| WOS关键词 | NECROSIS-FACTOR-ALPHA ; NF-KAPPA-B ; EPITHELIAL-MESENCHYMAL TRANSITION ; GROWTH-FACTOR-BETA ; HUMAN DERMAL FIBROBLASTS ; HUMAN ENDOTHELIAL-CELLS ; INDUCED UP-REGULATION ; BREAST-CANCER CELLS ; RECEPTOR-TYPE-II ; STEM-CELLS |
| 资助项目 | National Natural Science Foundation of China[81973595] ; National Natural Science Foundation of China[82004094] ; Support Program for Longyuan Youth ; Fundamental Research Funds for the Universities of Gansu Province[GZTZ[2021]17-1] ; Provincial university industry support project in Gansu[2020C-15] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000751014300001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Support Program for Longyuan Youth ; Fundamental Research Funds for the Universities of Gansu Province ; Provincial university industry support project in Gansu |
| 源URL | [http://119.78.100.186/handle/113462/142228]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Liu, Yong-qi |
| 作者单位 | 1.Gansu Univ Chinese Med, Tradit Chinese Med Res Gansu Coll & Univ, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China 2.First Peoples Hosp Lanzhou City, Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China 3.Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 5.Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhi-wei,Zhang, Yi-ming,Zhang, Li-ying,et al. Duality of Interactions Between TGF-beta and TNF-alpha During Tumor Formation[J]. FRONTIERS IN IMMUNOLOGY,2022,12:14. |
| APA | Liu, Zhi-wei.,Zhang, Yi-ming.,Zhang, Li-ying.,Zhou, Ting.,Li, Yang-yang.,...&Liu, Yong-qi.(2022).Duality of Interactions Between TGF-beta and TNF-alpha During Tumor Formation.FRONTIERS IN IMMUNOLOGY,12,14. |
| MLA | Liu, Zhi-wei,et al."Duality of Interactions Between TGF-beta and TNF-alpha During Tumor Formation".FRONTIERS IN IMMUNOLOGY 12(2022):14. |
入库方式： OAI收割
来源：近代物理研究所
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