Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies
文献类型：期刊论文
| 作者 | Wang, Dandan1,2; Liu, Ruifeng1,3,4; Zhang, Qiuning1,3,4; Luo, Hongtao1,3,4; Chen, Junru1,2; Dong, Meng1,2; Wang, Yuhang1,2; Ou, Yuhong1,2; Liu, Zhiqiang1,3,4; Sun, Shilong1,3,4 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-01-04 |
| 卷号 | 11页码:13 |
| 关键词 | pancreatic cancer particle radiation clonogenic survival DDR migration invasion systematic review |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2021.775597 |
| 通讯作者 | Zhang, Qiuning(zhangqn@impcas.ac.cn) ; Wang, Xiaohu(xhwang@impcas.ac.cn) |
| 英文摘要 | Purpose: Given the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic preclinical studies were scarce. We aimed to investigate the radiobiological effects of charged particle irradiation on pancreatic cancer cell lines.Methods: A systematic literature search was performed in EMBASE (OVID), Medline (OVID), and Web of Science databases. Included studies were in vitro English publications that reported the radiobiological effects of charged particle irradiation on pancreatic cancer cells.Results: Thirteen carbon ion irradiation and seven proton irradiation in vitro studies were included finally. Relative biological effectiveness (RBE) values of carbon ion irradiation and proton irradiation in different human pancreatic cancer cell lines ranged from 1.29 to 4.5, and 0.6 to 2.1, respectively. The mean of the surviving fraction of 2 Gy (SF2) of carbon ion, proton, and photon irradiation was 0.18 & PLUSMN; 0.11, 0.48 & PLUSMN; 0.11, and 0.57 & PLUSMN; 0.13, respectively. Carbon ion irradiation induced more G2/M arrest and a longer-lasting expression of gamma H2AX than photon irradiation. Combination therapies enhanced the therapeutic effects of pancreatic cell lines with a mean standard enhancement ratio (SER) of 1.66 & PLUSMN; 0.63 for carbon ion irradiation, 1.55 & PLUSMN; 0.27 for proton irradiation, and 1.52 & PLUSMN; 0.30 for photon irradiation. Carbon ion irradiation was more effective in suppressing the migration and invasion than photon irradiation, except for the PANC-1 cells.Conclusions: Current in vitro evidence demonstrates that, compared with photon irradiation, carbon ion irradiation offers superior radiobiological effects in the treatment of pancreatic cancer. Mechanistically, high-LET irradiation may induce complex DNA damage and ultimately promote genomic instability and cell death. Both carbon ion irradiation and proton irradiation confer similar sensitization effects in comparison with photon irradiation when combined with chemotherapy or targeted therapy. |
| WOS关键词 | LINEAR-ENERGY-TRANSFER ; CARBON-ION RADIATION ; INTENSITY-MODULATED PHOTON ; DNA-DAMAGE ; BIOLOGICAL EFFECTIVENESS ; CELL-LINES ; PROTON ; THERAPY ; GEMCITABINE ; BEAMS |
| 资助项目 | Science and Technology Plan Project of Chengguan District of Lanzhou[2020-2-2-5] ; Talent innovation and venture project of Lanzhou city[2017-RC-23] ; Talent innovation and venture project of Lanzhou city[2020-RC-113] ; Key R&D Program of Science and Technology Department of Gansu Province[20YF8FA116] ; Lanzhou KejinTaiji Corporation, Ltd.[BMP-B-02-002] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000747696100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Science and Technology Plan Project of Chengguan District of Lanzhou ; Talent innovation and venture project of Lanzhou city ; Key R&D Program of Science and Technology Department of Gansu Province ; Lanzhou KejinTaiji Corporation, Ltd. |
| 源URL | [http://119.78.100.186/handle/113462/142284]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Qiuning; Wang, Xiaohu |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China 3.Univ Chinese Acad Sci, Dept Postgrad, Beijing, Peoples R China 4.Lanzhou Heavy Hosp, Heavy Therapy Ctr, Lanzhou, Peoples R China 5.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dandan,Liu, Ruifeng,Zhang, Qiuning,et al. Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies[J]. FRONTIERS IN ONCOLOGY,2022,11:13. |
| APA | Wang, Dandan.,Liu, Ruifeng.,Zhang, Qiuning.,Luo, Hongtao.,Chen, Junru.,...&Wang, Xiaohu.(2022).Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies.FRONTIERS IN ONCOLOGY,11,13. |
| MLA | Wang, Dandan,et al."Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies".FRONTIERS IN ONCOLOGY 11(2022):13. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。