Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study
文献类型:期刊论文
作者 | Wang, Yan-yu1,2,3; Wang, Yi2,3,4; Huang, Jia2,3,4; Sun, Xi-he5; Wang, Xi-zhen5; Zhang, Shu-xian5; Zhu, Guo-hui6; Lui, Simon S. Y.7; Cheung, Eric F. C.8; Sun, Hong-wei1 |
刊名 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE |
出版日期 | 2022-01-26 |
页码 | 13 |
通讯作者邮箱 | rckchan@psych.ac.cn (raymond c. k. chan ) |
ISSN号 | 0940-1334 |
关键词 | Anhedonia Effort expenditure for reward task Functional imaging Transdiagnostic Mental disorder |
DOI | 10.1007/s00406-021-01376-3 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | Unwillingness to exert effort for rewards has been found in patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD), but the underlying shared and distinct reward neural mechanisms remain unclear. This study aimed to compare the neural correlates of such impairments across different diagnoses. The neural responses in an effort-expenditure for reward task (EEfRT) were assessed in 20 SCZ patients, 23 MDD patients, 17 BD patients, and 30 healthy controls (HC). The results found shared activation in the cingulate gyrus, the medial frontal gyrus, and the middle frontal gyrus during the EEfRT administration. Compared to HC, SCZ patients exhibited stronger variations of functional connectivity between the right caudate and the left amygdala, the left hippocampus and the left putamen, with increase in reward magnitude. In MDD patients, an enhanced activation compared to HC in the right superior temporal gyrus was found with the increase of reward magnitude. The variations of functional connectivity between the caudate and the right cingulate gyrus, the left postcentral gyrus and the left inferior parietal lobule with increase in reward magnitude were weaker than that found in HC. In BD patients, the degree of activation in the left precuneus was increased, but that in the left dorsolateral prefrontal cortex was decreased with increase in reward probability compared to HC. These findings demonstrate both shared and distinct reward neural mechanisms associated with EEfRT in patients with SCZ, MDD, and BD, implicating potential intervention targets to alleviate amotivation in these clinical disorders. |
收录类别 | SCI |
WOS关键词 | BEHAVIORAL-APPROACH SYSTEM ; DECISION-MAKING ; SPECTRUM DISORDERS ; NEGATIVE SYMPTOMS ; EFFORT ALLOCATION ; ANHEDONIA ; DYSFUNCTION ; ACTIVATION ; DEFICITS ; MOOD |
资助项目 | National Key Research and Development Programme[2016YFC0906402] ; National Science Fund China[81571317] ; National Science Fund China[31871114] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Philip K. H. Wong Foundation ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Natural Science Foundation of Shandong Province[ZR2017LC023] ; Natural Science Foundation of Shandong Province[ZR2017MH110] ; Humanities and Social Sciences Research Project of Ministry of Education[19YJA190006] |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | SPRINGER HEIDELBERG |
WOS记录号 | WOS:000746793300001 |
资助机构 | National Key Research and Development Programme ; National Science Fund China ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for the Leading Talents in Science and Technology ; Philip K. H. Wong Foundation ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Natural Science Foundation of Shandong Province ; Humanities and Social Sciences Research Project of Ministry of Education |
源URL | [http://ir.psych.ac.cn/handle/311026/41894] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Weifang Med Univ, Sch Psychol, Weifang 261053, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, 16 Lincui Rd, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100048, Peoples R China 5.Weifang Med Univ, Magnet Resonance Imaging Ctr, Affiliated Hosp, Weifang 261031, Shandong, Peoples R China 6.Mental Hlth Ctr Weifang City, Weifang 261071, Shandong, Peoples R China 7.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China 8.Castle Peak Hosp, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yan-yu,Wang, Yi,Huang, Jia,et al. Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2022:13. |
APA | Wang, Yan-yu.,Wang, Yi.,Huang, Jia.,Sun, Xi-he.,Wang, Xi-zhen.,...&Chan, Raymond C. K..(2022).Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,13. |
MLA | Wang, Yan-yu,et al."Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022):13. |
入库方式: OAI收割
来源:心理研究所
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