Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
文献类型:期刊论文
作者 | Dennis, Emily L.3,4,5,6; Disner, Seth G.7,8; Fani, Negar9; Salminen, Lauren E.4; Logue, Mark10,11,12,13; Clarke, Emily K.14,15; Haswell, Courtney C.14,15; Averill, Christopher L.16,17; Baugh, Lee A.18,19,20; Bomyea, Jessica21,22 |
刊名 | MOLECULAR PSYCHIATRY |
出版日期 | 2021-08-01 |
卷号 | 26期号:8页码:4315-4330 |
通讯作者邮箱 | dennis, emily l. |
ISSN号 | 1359-4184 |
DOI | 10.1038/s41380-019-0631-x |
文献子类 | 实证研究 |
英文摘要 | A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network. |
收录类别 | SCI |
WOS关键词 | SMALLER HIPPOCAMPAL VOLUME ; FRACTIONAL ANISOTROPY ; STRUCTURAL INTEGRITY ; NEUROTROPHIC FACTOR ; TRACT INTEGRITY ; ABNORMALITIES ; CONNECTIVITY ; COMORBIDITY ; PREVALENCE ; MULTISITE |
资助项目 | CIHR ; CIMVHR ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship[R01MH043454] ; National Science Foundation Graduate Research Fellowship[T32MH018931] ; National Institute of Child Health and Human Development[P30HD003352] ; Defense and Veterans Brain Injury Centers ; U.S. Army Medical Research and Materiel Command (USAMRMC)[W81XWH-13-2-0025] ; Chronic Effects of Neurotrauma Consortium (CENC)[PT108802-SC104835] ; Department of Defense[W81XWH-12-2-0012] ; NIH from the Big Data to Knowledge (BD2K) program[U54EB020403] ; NIH from the Big Data to Knowledge (BD2K) program[R56AG058854] ; NIH from the Big Data to Knowledge (BD2K) program[R01MH116147] ; NIH from the Big Data to Knowledge (BD2K) program[R01MH111671] ; NIH from the Big Data to Knowledge (BD2K) program[P41EB015922] ; Department of Veterans Affairs ; NIAAA ; NCATS ; DoD[W81XWH-101-0925] ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant[F32MH109274] ; Bill & Melinda Gates Foundation ; SAMRC Unit on Risk & Resilience in Mental Disorders ; German Research Foundation grant[1222/4-1] ; German Research Foundation grant[1539/8-2] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[SFB/TRR 58] ; Clinical Science Research and Development Service, VA Office of Research and Development[MH098212] ; Clinical Science Research and Development Service, VA Office of Research and Development[MH071537] ; Clinical Science Research and Development Service, VA Office of Research and Development[M01RR00039] ; Clinical Science Research and Development Service, VA Office of Research and Development[UL1TR000454] ; Clinical Science Research and Development Service, VA Office of Research and Development[HD071982] ; Clinical Science Research and Development Service, VA Office of Research and Development[HD085850] ; Clinical Science Research and Development Service, VA Office of Research and Development[MH101380] ; NARSAD[27040] ; NARSAD[K01MH109836] ; Young Investigator Grant, Korean Scientists and Engineers Association ; NHMRC Program[R01MH111671] ; NHMRC Program[1073041] ; NHMRC Program[R01AG050595] ; NHMRC Program[R01AG022381] ; NHMRC Program[R01AG058822] ; NHMRC Program[R01EB015611] ; NHMRC Program[R01MH105355] ; NHMRC Program[R01DA035484] ; NHMRC Program[R01MH117601] ; NHMRC Program[R01AG059874] ; NHMRC Program[MJFF 14848] ; NHMRC Program[VISN6 MIRECC] ; NHMRC Program[R21MH112956] ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; South African Medical Research Council[MRC-RFA-IFSP01-2013/SHARED ROOTS] ; South African National Treasury under its Economic Competitiveness and Support Package ; South African Medical Research Council through its Division of Research Capacity Development under the SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME from the South African National Treasury ; South African Research Chairs Initiative in Posttraumatic Stress Disorder through the Department of Science and Technology ; National Research Foundation ; National Natural Science Foundation of China[31271099] ; National Natural Science Foundation of China[31471004] ; Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4] ; ZonMw ; Netherlands organization for Health Research and Development[4000812-98-10041] ; Academic Medical Center Research Council[110614] ; Translational Research Center for TBI and Stress Disorders (TRACTS) ; VA Rehabilitation Research and Development (RR&D) Traumatic Brain Injury Center of Excellence at VA Boston Healthcare System[B9254-C] ; VA CSRD[1IK2CX001680] ; VISN17 Center of Excellence Pilot funding ; VA RRD[1IK2RX000709] ; VA RRD[1K1RX002325] ; VA RRD[1K2RX002922] ; VA RRD[I01RX000622] ; CDMRP from the US Department of Defense[W81XWH-08-2-0038] ; CDMRP from the US Department of Defense[W81XWH08-2-0159] ; [K99NS096116] ; [I01-CX000715] ; [I01-CX001542] ; [K01MH118428] ; [K23MH090366] ; [K2CX001772] |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | SPRINGERNATURE |
WOS记录号 | WOS:000731712800056 |
资助机构 | CIHR ; CIMVHR ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship ; National Institute of Child Health and Human Development ; Defense and Veterans Brain Injury Centers ; U.S. Army Medical Research and Materiel Command (USAMRMC) ; Chronic Effects of Neurotrauma Consortium (CENC) ; Department of Defense ; NIH from the Big Data to Knowledge (BD2K) program ; Department of Veterans Affairs ; NIAAA ; NCATS ; DoD ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant ; Bill & Melinda Gates Foundation ; SAMRC Unit on Risk & Resilience in Mental Disorders ; German Research Foundation grant ; German Research Society (Deutsche Forschungsgemeinschaft, DFG) ; Clinical Science Research and Development Service, VA Office of Research and Development ; NARSAD ; Young Investigator Grant, Korean Scientists and Engineers Association ; NHMRC Program ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; South African Medical Research Council ; South African National Treasury under its Economic Competitiveness and Support Package ; South African Medical Research Council through its Division of Research Capacity Development under the SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME from the South African National Treasury ; South African Research Chairs Initiative in Posttraumatic Stress Disorder through the Department of Science and Technology ; National Research Foundation ; National Natural Science Foundation of China ; Research Program of the Chinese Academy of Sciences ; ZonMw ; Netherlands organization for Health Research and Development ; Academic Medical Center Research Council ; Translational Research Center for TBI and Stress Disorders (TRACTS) ; VA Rehabilitation Research and Development (RR&D) Traumatic Brain Injury Center of Excellence at VA Boston Healthcare System ; VA CSRD ; VISN17 Center of Excellence Pilot funding ; VA RRD ; CDMRP from the US Department of Defense |
源URL | [http://ir.psych.ac.cn/handle/311026/41900] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Dennis, Emily L. |
作者单位 | 1.Univ Iowa, Dept Radiol, Iowa City, IA USA 2.Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Dallas, TX USA 3.Brigham & Womens Hosp, Psychiat Neuroimaging Lab, Dept Psychiat, 75 Francis St, Boston, MA 02115 USA 4.USC, Imaging Genet Ctr, Stevens Neuroimaging & Informat Inst, Keck Sch Med, Marina Del Rey, CA 90292 USA 5.Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA 6.Stanford Neurodev Affect & Psychopathol Lab, Stanford, CA 94305 USA 7.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 8.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 9.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA 10.VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA |
推荐引用方式 GB/T 7714 | Dennis, Emily L.,Disner, Seth G.,Fani, Negar,et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium[J]. MOLECULAR PSYCHIATRY,2021,26(8):4315-4330. |
APA | Dennis, Emily L..,Disner, Seth G..,Fani, Negar.,Salminen, Lauren E..,Logue, Mark.,...&Morey, Rajendra A..(2021).Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.MOLECULAR PSYCHIATRY,26(8),4315-4330. |
MLA | Dennis, Emily L.,et al."Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium".MOLECULAR PSYCHIATRY 26.8(2021):4315-4330. |
入库方式: OAI收割
来源:心理研究所
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